Department of Pharmacy, 302 Military Hospital of China, Beijing, 100039, China.
China Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing, 100039, China.
Mini Rev Med Chem. 2019;19(2):125-137. doi: 10.2174/1389557518666181017143141.
Infectious diseases caused by pathogenic bacteria seriously threaten human lives. Although antibiotic therapy is effective in the treatment of bacterial infections, the overuse of antibiotics has led to an increased risk of antibiotic resistance, putting forward urgent requirements for novel antibacterial drugs. Traditional Chinese herbal medicine (TCHM) and its constituents are considered to be potential sources of new antimicrobial agents. Currently, a series of chemical compounds purified from TCHM have been reported to fight against infections by drug-resistant bacteria. In this review, we summarized the recent findings on TCHM-derived compounds treating drug-resistant bacterial infections. Further studies are still needed for the discovery of potential antibacterial components from TCHM.
由病原菌引起的传染病严重威胁着人类的生命。虽然抗生素疗法在治疗细菌感染方面具有疗效，但抗生素的过度使用导致了抗生素耐药性的风险增加，这对新型抗菌药物提出了迫切的要求。传统中药（TCM）及其成分被认为是新型抗菌药物的潜在来源。目前，已经有一系列从 TCM 中分离出的化学化合物被报道可以对抗耐药菌引起的感染。在这篇综述中，我们总结了 TCM 衍生化合物治疗耐药菌感染的最新研究进展。为了从 TCM 中发现有潜力的抗菌成分，还需要进一步的研究。
