Patel Gayatri, Yadav Bindu Kumari N
Ramanbhai Patel College of Pharmacy, Charotar University of Science Technology, Changa, Anand, Gujarat, India.
Recent Pat Nanotechnol. 2018;12(3):174-179. doi: 10.2174/1872210512666181017122032.
In the recent years, polymeric nanofibers have gained lots of attention in the area of drug delivery applications. Owing to its simplicity, ease of composition method and high drug loading capacity, it provides various benefits for the therapeutic applications. Nanofibers are useful for the delivery of antibiotics, anticancer drugs, analgesic's agents and various proteins for drug delivery applications. Electrospinning method is widely used method for the preparation of nanofibers, based on their feasibility background for scale-up process from laboratory to the industrial applications.
A literature review was conducted to summarize the reported articles as well as patents that have been granted and filed for work related to nanofibers in drug delivery. Efforts have been made to include various types of research undertaken by the researchers for the fabrication of nanofiber and its application in drug delivery system.
In this paper, a detailed information is reported about researches and developments related to electrospun polymer nanofibers including its fabrication process, structure, properties, characterization, applications, and patent. Amongst all the patents available, 18 most relevant granted patents and 14 filed patents was summarized in the review article.
We expect that these fundamental applications of nanofibers could help the researchers to develop and gain knowledge about nanofibers in drug delivery application.
近年来，聚合物纳米纤维在药物递送应用领域备受关注。由于其制备方法简单、易于合成且药物负载能力高，它为治疗应用带来了诸多益处。纳米纤维可用于递送抗生素、抗癌药物、镇痛剂以及用于药物递送应用的各种蛋白质。基于从实验室规模扩大到工业应用的可行性背景，静电纺丝法是制备纳米纤维广泛使用的方法。
进行了文献综述，以总结已报道的文章以及已授予和提交的与纳米纤维在药物递送方面相关工作的专利。已努力纳入研究人员为制造纳米纤维及其在药物递送系统中的应用所开展的各类研究。
本文报道了有关静电纺丝聚合物纳米纤维的研究与开发的详细信息，包括其制造工艺、结构、性能、表征、应用和专利。在所有可用专利中，综述文章总结了18项最相关的已授予专利和14项已提交专利。
我们期望纳米纤维的这些基础应用能够帮助研究人员在药物递送应用中开发并了解纳米纤维。
