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J Clin Microbiol. 2019 Mar 28;57(4). doi: 10.1128/JCM.01173-18. Print 2019 Apr.

本文引用的文献

1
Strongyloides stercoralis in solid organ transplantation: early diagnosis gets the worm.实体器官移植中的粪类圆线虫：早期诊断可成功驱虫。
Curr Opin Organ Transplant. 2017 Aug;22(4):336-344. doi: 10.1097/MOT.0000000000000428.
2
StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control.强力网：一个改善粪类圆线虫病诊断及治疗可及性以进行疾病控制的国际网络。
PLoS Negl Trop Dis. 2016 Sep 8;10(9):e0004898. doi: 10.1371/journal.pntd.0004898. eCollection 2016 Sep.
3
Subcutaneous ivermectin use in the treatment of severe Strongyloides stercoralis infection: two case reports and a discussion of the literature.皮下注射伊维菌素治疗重度粪类圆线虫感染：两例病例报告及文献讨论
J Antimicrob Chemother. 2016 Jan;71(1):220-5. doi: 10.1093/jac/dkv315. Epub 2015 Oct 12.
4
Strongyloidiasis--an insight into its global prevalence and management.类圆线虫病——对其全球流行情况及管理的深入了解。
PLoS Negl Trop Dis. 2014 Aug 14;8(8):e3018. doi: 10.1371/journal.pntd.0003018. eCollection 2014 Aug.
5
Strongyloides stercoralis: a plea for action.粪类圆线虫：呼吁采取行动。
PLoS Negl Trop Dis. 2013 May 9;7(5):e2214. doi: 10.1371/journal.pntd.0002214. Print 2013.
6
Severe strongyloidiasis: a systematic review of case reports.严重的类圆线虫病：病例报告的系统评价。
BMC Infect Dis. 2013 Feb 8;13:78. doi: 10.1186/1471-2334-13-78.
7
Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis.筛查、预防和治疗粪类圆线虫引起的超感染综合征和播散性感染。
Curr Opin Infect Dis. 2012 Aug;25(4):458-63. doi: 10.1097/QCO.0b013e3283551dbd.
8
Sexual transmission of intestinal parasites in men who have sex with men.男男性行为者中肠道寄生虫的性传播。
Sex Health. 2009 Sep;6(3):185-94. doi: 10.1071/SH08084.
9
Strongyloides colitis is a lethal mimic of ulcerative colitis: the key morphologic differential diagnosis.类圆线虫性结肠炎是溃疡性结肠炎的致命性模仿疾病：关键的形态学鉴别诊断
Hum Pathol. 2009 Apr;40(4):572-7. doi: 10.1016/j.humpath.2008.10.008. Epub 2009 Jan 13.
10
Strongyloides stercoralis: a cause of morbidity and mortality for indigenous people in Central Australia.粪类圆线虫：澳大利亚中部原住民发病和死亡的一个原因。
Intern Med J. 2008 Sep;38(9):697-703. doi: 10.1111/j.1445-5994.2008.01775.x.

病例报告：播散性感染中的皮下伊维菌素药代动力学：血浆和尸检分析。

Case Report: Subcutaneous Ivermectin Pharmacokinetics in Disseminated Infection: Plasma and Postmortem Analysis.

机构信息

University of New South Wales, Sydney, Australia.

St. George Hospital, Sydney, Australia.

出版信息

Am J Trop Med Hyg. 2018 Dec;99(6):1580-1582. doi: 10.4269/ajtmh.18-0387. Epub 2018 Sep 13.

DOI:10.4269/ajtmh.18-0387
PMID:30334520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6283511/
Abstract

Parenteral ivermectin treatment of disseminated strongyloidiasis and hyperinfection is increasing, although not licensed in humans and with limited pharmacokinetic data available. Plasma and postmortem tissue analysis in an human immunodeficiency virus (HIV)/hepatitis C virus-positive man with disseminated strongyloidiasis suggests loading subcutaneous ivermectin doses are required, from which the central nervous system is protected.

摘要

尽管伊维菌素尚未在人体获得许可，且药代动力学数据有限，但人们越来越多地使用伊维菌素进行肠外治疗播散性旋毛虫病和超感染，这是一种治疗方法。对一名患有播散性旋毛虫病的人类免疫缺陷病毒（HIV）/丙型肝炎病毒阳性患者进行血浆和尸检组织分析后表明，需要给予皮下伊维菌素负荷剂量，以保护中枢神经系统。