Sun Weipeng, Li Minying, Lin Tong, Sun Zhizhong, Xie Yizi, Ji Shuliang, Lin Jietao, Wang Lin, Jia Chao, Zheng Liang, Wu Wei, Xu Danghan
First Clinical College.
Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine.
Medicine (Baltimore). 2018 Oct;97(42):e12892. doi: 10.1097/MD.0000000000012892.
Vascular dementia (VD) is a commonly-seen disease in the elderly. What is more, "Acupuncture at 3-points for intelligence" is one of the most important components of "Jin's three-needle therapy" created by Rui Jin, a professor of Guangzhou University of Chinese Medicine, which can be used in the VD patients. In this article, researchers will assess the clinical efficacy and safety of acupuncture at 3-points for intelligence in the treatment of VD.
A systematic literature search for articles up to September 2018 will be conducted using 9 databases: PubMed, Cochrane Library, Embase, CNKI, CBM, VIP, Wanfang database, OASIS, and CiNii. Inclusion criteria are randomized controlled trials (RCTs) of acupuncture at 3-points for intelligence on treating VD. The primary outcome measures will be scores reflecting the neurological function of participants based on common medical scales. Hemorheology indexes, homocysteine (Hcy), acetylcholine (Ach), nitric oxide (NO), and adverse events will also be assessed. Stata V.13.0 software will be used for data synthesis, sensitivity analysis, meta-regression, subgroup analysis, and risk of bias assessment. A funnel plot will be developed to evaluate reporting bias. Egger and Begg tests will be further performed to conduct quantitative evaluation of publication bias and to evaluate the symmetry of funnel plot. We will use the Grading of Recommendations Assessment, Development, and Evaluation system to assess the quality of evidence.
The results of this systematic review and meta-analysis will be published in a peer-reviewed journal.
Our study will provide the evidence for the clinical efficacy and safety of acupuncture at 3-points for intelligence in the treatment of VD.
血管性痴呆（VD）是老年人的常见疾病。此外，“智三针”是广州中医药大学教授靳瑞所创“靳三针疗法”的重要组成部分，可用于VD患者。在本文中，研究人员将评估智三针治疗VD的临床疗效和安全性。
将使用9个数据库进行系统文献检索，检索截至2018年9月的文章，这些数据库包括：PubMed、Cochrane图书馆、Embase、中国知网（CNKI）、中国生物医学文献数据库（CBM）、维普资讯（VIP）、万方数据库、OASIS和CiNii。纳入标准为智三针治疗VD的随机对照试验（RCT）。主要结局指标将是基于常用医学量表反映参与者神经功能的评分。还将评估血液流变学指标、同型半胱氨酸（Hcy）、乙酰胆碱（Ach）、一氧化氮（NO）及不良事件。将使用Stata V.13.0软件进行数据合成、敏感性分析、Meta回归、亚组分析和偏倚风险评估。将绘制漏斗图以评估报告偏倚。将进一步进行Egger检验和Begg检验，以对发表偏倚进行定量评估并评估漏斗图的对称性。我们将使用推荐分级评估、制定和评价系统来评估证据质量。
本系统评价和Meta分析的结果将发表在同行评审期刊上。
我们的研究将为智三针治疗VD的临床疗效和安全性提供证据。
