通过铜催化的 2-乙烯基苄基醇的对映选择性环化/碳醚化反应合成邻苯二甲酸酐。
Synthesis of Phthalans Via Copper-Catalyzed Enantioselective Cyclization/Carboetherification of 2-Vinylbenzyl Alcohols.
机构信息
Department of Chemistry , State University of New York at Buffalo , Buffalo , New York 14260 , United States.
出版信息
Org Lett. 2018 Oct 19;20(20):6453-6456. doi: 10.1021/acs.orglett.8b02766. Epub 2018 Oct 11.
Abstract
Enantiomerically enriched phthalans were synthesized efficiently via an enantioselective copper-catalyzed alkene carboetherification reaction. In this reaction, 2-vinylbenzyl alcohols enantioselectively cyclize then couple with vinylarenes. The utility of the method was demonstrated by the enantioselective synthesis of ( R)-fluspidine, a σ receptor ligand.
摘要
通过对映体富集的邻苯二甲酸酐可通过对映选择性铜催化烯烃碳醚化反应高效合成。在该反应中，2-乙烯基苄醇对映选择性环化然后与乙烯基芳烃偶联。该方法的实用性通过（R）-fluspidine（一种σ受体配体）的对映选择性合成得到了证明。
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