Jones Charlotte J Maughan, Munro Peter R T
Department of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, University College London, London WC1E 6BT, UK.
School of Electrical, Electronic and Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, Western Australia 6009, Australia.
Biomed Opt Express. 2018 Jul 2;9(8):3495-3502. doi: 10.1364/BOE.9.003495. eCollection 2018 Aug 1.
Phantoms with tuneable optical scattering properties are essential in the development and refinement of optical based imaging techniques. Mineral oil based 'gel wax' phantoms are the subject of increasing interest due to their ease and speed of manufacture, non-toxic nature, ability to cast into anatomically realistic shapes, as well as their cost-effective nature of production. The addition of scatterers such as titanium dioxide powder and monodisperse silica microspheres to the gel wax allows for the creation of phantoms with a controllable optical scattering coefficient. To enable repeated use of such phantoms, the stability of the scattering properties must be determined-a property which has yet to be investigated. We present an analysis of the stability of the reduced scattering coefficient ( ) of such phantoms over time. We conclude that due to the measurable reduction in scattering coefficient over time, gel wax phantoms embedded with silica spheres may not be suitable for repeated use over time, however gel wax-TiO phantoms are much more temporally stable.
具有可调光学散射特性的体模对于基于光学的成像技术的开发和完善至关重要。基于矿物油的“凝胶蜡”体模因其制造简便、速度快、无毒、能够浇铸出符合解剖学实际形状以及生产成本效益高的特点而受到越来越多的关注。向凝胶蜡中添加诸如二氧化钛粉末和单分散二氧化硅微球等散射体，可以制造出具有可控光学散射系数的体模。为了能够重复使用此类体模，必须确定散射特性的稳定性——这一特性尚未得到研究。我们对这类体模的约化散射系数随时间的稳定性进行了分析。我们得出结论，由于随着时间的推移散射系数有可测量的降低，嵌入二氧化硅球的凝胶蜡体模可能不适合长期重复使用，然而凝胶蜡 - 二氧化钛体模在时间上要稳定得多。
