Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Cidade Universitária, CCS - Bl. I, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil.
Eur J Clin Microbiol Infect Dis. 2019 Jan;38(1):135-139. doi: 10.1007/s10096-018-3404-6. Epub 2018 Oct 18.
Despite the growing importance of infections caused by the human polyomaviruses (HPyVs), information about their transmission, pathogenesis, and epidemiology is scarce. The objective of this work was to evaluate the excretion and distribution of HPyV (HPyV1-HPyV4 [former BKPyV, JCPyV, KIPyV, and WUPyV, respectively]) among asymptomatic individuals from different geographic regions in Brazil, in order to verify the existence of distinct epidemiologic patterns among the Brazilian population. Saliva samples from 889 healthy volunteers living in nine locations in Brazil were analyzed by real-time polymerase chain reaction (PCR) to detect HPyV1-4. Among 889 participants, 346 (39%) had evidence of infection with one or more HPyV species: 127 (14.3%) had HPyV1 only; 70 (7.9%) had HPyV3 only; 60 (6.7%) had HPyV4 only, and 25 (2.8%) had HPyV2 only. Coinfections were detected in 64 participants (7.3%). Although HPyV excretion was detected in samples from all locations, the frequency and distribution of viral species varied significantly. The epidemiologic findings presented demonstrate that the four HPyV species studied are circulating in five geographic regions of Brazil. Salivary excretion of these viruses appears common among healthy Brazilians. The distribution of viral species varies considerably between regions as well as within regions.
尽管人类多瘤病毒（HPyV）引起的感染越来越重要，但关于其传播、发病机制和流行病学的信息仍然匮乏。本研究旨在评估巴西不同地区无症状个体中 HPyV（HPyV1-HPyV4[分别为 BKPyV、JCPyV、KIPyV 和 WUPyV]）的排泄和分布情况，以验证巴西人群中是否存在不同的流行模式。通过实时聚合酶链反应（PCR）分析了来自巴西 9 个地区的 889 名健康志愿者的唾液样本，以检测 HPyV1-4。在 889 名参与者中，有 346 名（39%）存在一种或多种 HPyV 感染的证据：127 名（14.3%）仅感染 HPyV1；70 名（7.9%）仅感染 HPyV3；60 名（6.7%）仅感染 HPyV4；25 名（2.8%）仅感染 HPyV2。64 名参与者（7.3%）存在混合感染。尽管在所有地区的样本中均检测到 HPyV 排泄，但病毒种类的频率和分布存在显著差异。本研究的流行病学发现表明，研究的四种 HPyV 均在巴西的五个地理区域流行。这些病毒在健康巴西人群中唾液排泄似乎很常见。病毒种类在不同地区以及同一地区的分布差异很大。
