State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Bioorg Chem. 2019 Mar;83:20-28. doi: 10.1016/j.bioorg.2018.08.039. Epub 2018 Sep 5.
Eight new iridal-type triterpenoid derivatives, including two noriridals with ether bridge (1-2); two iridals lactone (3-4), four monocyclic iridals (5-8), together with five known iridals (9-14) were identified from the rhizome of Belamcanda chinensis. Their structures were elucidated on the basis of comprehensive spectroscopic methods and electronic circular dichroism (ECD) calculations. Bioassay results showed that belamcanoxide B (1) exhibited moderated cytotoxic activities against HCT-116 and MCF-7 cell lines with IC values of 5.58 and 3.35 μM.
从射干根茎中分离得到 8 个新的鸢尾型三萜类衍生物，包括 2 个具有醚桥的新 noriridals（1-2）；2 个 iridals 内酯（3-4），4 个单环 iridals（5-8），以及 5 个已知的 iridals（9-14）。基于综合光谱方法和电子圆二色谱（ECD）计算，确定了它们的结构。生物测定结果表明，射干苷 B（1）对 HCT-116 和 MCF-7 细胞系具有中等的细胞毒性活性，IC 值分别为 5.58 和 3.35 μM。
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