从. 的根茎中分离得到具有环戊烷单元的艾里哒型三萜类化合物
Iridal-Type Triterpenoids with a Cyclopentane Unit from the Rhizomes of .
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , People's Republic of China.
出版信息
J Nat Prod. 2019 Jul 26;82(7):1759-1767. doi: 10.1021/acs.jnatprod.8b00993. Epub 2019 Jun 27.
Ten new iridal-type triterpenoid derivatives, polycycloiridals K-T (-), with a cyclopentane moiety originating from the cyclization of the homofarnesyl side chain were isolated from the rhizomes of . Their structures were established by spectroscopic data, a single-crystal X-ray diffraction analysis, TDDFT quantum mechanical calculations, and chemical derivatization. Compounds and exhibited 33.4% and 32.9% inhibitory activities, respectively, against PTP1b (protein tyrosine phosphatase) at a concentration of 10 μM. A putative biosynthetic pathway is proposed.
从 的根茎中分离得到了 10 个新的艾里多烷型三萜衍生物，多环艾里多尔 K-T(-)，它们具有来源于 homofarnesyl 侧链环化的环戊烷部分。通过光谱数据、单晶 X 射线衍射分析、TDDFT 量子力学计算和化学衍生化，确定了它们的结构。化合物 和 分别在 10 μM 浓度下对 PTP1b（蛋白酪氨酸磷酸酶）表现出 33.4%和 32.9%的抑制活性。提出了一个可能的生物合成途径。
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