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Culmination of a half-century quest reveals insight into mutant tRNA-mediated frameshifting after tRNA departure from the decoding site.

作者信息

Atkins John F

机构信息

School of Biochemistry and Cell Biology, University College Cork, Cork T12 YT57, Ireland;

Department of Human Genetics, University of Utah, Salt Lake City, UT 84112.

出版信息

Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):11121-11123. doi: 10.1073/pnas.1815837115. Epub 2018 Oct 19.

Abstract
摘要

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本文引用的文献

1
Mechanism of tRNA-mediated +1 ribosomal frameshifting.
Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):11226-11231. doi: 10.1073/pnas.1809319115. Epub 2018 Sep 27.
2
Expanding and reprogramming the genetic code.
Nature. 2017 Oct 4;550(7674):53-60. doi: 10.1038/nature24031.
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Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.
Nucleic Acids Res. 2016 Sep 6;44(15):7007-78. doi: 10.1093/nar/gkw530. Epub 2016 Jul 19.
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The large ribosomal subunit protein L9 enables the growth of EF-P deficient cells and enhances small subunit maturation.
PLoS One. 2015 Apr 16;10(4):e0120060. doi: 10.1371/journal.pone.0120060. eCollection 2015.
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Structure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM.
Nature. 2015 Apr 23;520(7548):567-70. doi: 10.1038/nature14275. Epub 2015 Feb 23.
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Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops.
Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12740-5. doi: 10.1073/pnas.1409436111. Epub 2014 Aug 15.
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Mechanisms and implications of programmed translational frameshifting.
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