Aschan G, Bunnfors I, Hydén D, Larsby B, Odkvist L M, Tham R
Acta Otolaryngol. 1977 Nov-Dec;84(5-6):370-6. doi: 10.3109/00016487709123979.
Complaints of vertigo from people who are exposed to industrial solvents have focused interest on their toxic effect on the nervous system. In order to evaluate the influence of an organic solvent, xylene, on the mammalian vestibular system, a series of rabbit experiments were performed. To achieve a constant concentration, the xylene was infused as a lipid emulsion. Blood concentrations were estimated by gas chromatography. Electronystagmography in darkness revealed that at blood xylene concentrations of 30 ppm all rabbits had a positional nystagmus. The beat direction was the opposite of positional alcohol nystagmus. Another difference between the alcohol and the xylene reaction was that rotatory nystagmus responses were exaggerated. The relations between the present findings and the reactions and blood concentrations in people exposed to industrial solvents are discussed.
接触工业溶剂的人所诉说的眩晕症状引发了人们对这些溶剂对神经系统毒性作用的关注。为了评估有机溶剂二甲苯对哺乳动物前庭系统的影响，进行了一系列家兔实验。为达到恒定浓度，二甲苯以脂质乳剂的形式注入。通过气相色谱法估算血液浓度。黑暗中的眼震电图显示，当血液中二甲苯浓度达到30 ppm时，所有家兔都出现了位置性眼震。其跳动方向与位置性酒精性眼震相反。酒精和二甲苯反应的另一个差异在于，旋转性眼震反应更为强烈。本文还讨论了这些研究结果与接触工业溶剂的人的反应及血液浓度之间的关系。
