关于工业溶剂引起前庭功能障碍的机制

On the mechanism of vestibular disturbances caused by industrial solvents.

作者信息

Odkvist L M, Larsby B, Tham R, Aschan G

出版信息

Adv Otorhinolaryngol. 1979;25:167-72. doi: 10.1159/000402937.

Abstract

The industrial solvents xylene, styrene, trichloroethylene and methylchloroform administered to rabbits caused a positional nystagmus and disturbances in the nystagmus response to rotatory acceleration. The positional nystagmus had a beat direction the opposite to positional alcohol nystagmus, which was in similar experiments elicited by methanol, ethanol and propanol. The three alcohols needed a ten times higher blood concentration to cause a nystagmus than the solvents did.

摘要

给兔子施用工业溶剂二甲苯、苯乙烯、三氯乙烯和甲基氯仿会导致位置性眼球震颤以及对旋转加速的眼球震颤反应紊乱。这种位置性眼球震颤的跳动方向与位置性酒精性眼球震颤相反，在类似实验中，甲醇、乙醇和丙醇会引发位置性酒精性眼球震颤。与这些溶剂相比，这三种醇类需要高出十倍的血液浓度才能引发眼球震颤。