Tham R, Larsby B, Eriksson B, Bunnfors I, Odkvist L, Liedgren C
Acta Otolaryngol. 1982 Jan-Feb;93(1-2):107-12. doi: 10.3109/00016488209130859.
A previously described experimental model for studying the effect of industrial solvents in the vestibular system of rabbits has been applied to rats. To achieve a constant concentration, the solvent was infused intravenously, dissolved in a lipid emulsion. Arterial blood levels were estimated by gas chromatography. The vestibulo-oculomotor behaviour of rats during repeated rotatory acceleration was investigated by electronystagmography. The effect of two solvents-toluene and styrene-on the rotatory induced nystagmus was examined. Both solvents caused an exaggerated reaction at arterial blood levels above 75 ppm. The investigation indicated that the rat will be suitable species for further electronystagmographic investigation of the influence of organic solvents on the vestibular system, for example in screening studies of the toxicity of these solvents.
一种先前描述的用于研究工业溶剂对家兔前庭系统影响的实验模型已应用于大鼠。为达到恒定浓度，将溶剂溶解在脂质乳剂中静脉输注。通过气相色谱法估算动脉血水平。通过眼震电图研究大鼠在反复旋转加速过程中的前庭眼动行为。研究了两种溶剂——甲苯和苯乙烯——对旋转诱发眼震的影响。两种溶剂在动脉血水平高于75 ppm时均引起过度反应。该研究表明，大鼠将是用于进一步通过眼震电图研究有机溶剂对前庭系统影响的合适物种，例如在这些溶剂的毒性筛查研究中。
