Alizargar Javad, Bai Chyi-Huey
School of Public Health, College of Public Health, Taipei Medical University, Taipei 11031, Taiwan.
Department of Public Health, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Medicina (Kaunas). 2018 Oct 11;54(5):71. doi: 10.3390/medicina54050071.
: Hypertension (HTN) is an important risk factor for cardiovascular diseases. High blood pressure is a major cause of atherosclerosis which leads to myocardial infarction and stroke. Insulin resistance (IR) is correlated with HTN and atherosclerosis. To determine differences between the effects of HTN on the intima media thicknesses (IMTs) of the internal (ICA), external (ECA), and common carotid arteries (CCA), and evaluate the carotid plaque presence between hypertensive and normotensive individuals, a case-control study was designed among community-dwelling individuals. The relationship between the triglyceride glucose (TyG) index and atherosclerosis was also investigated in this study. : Data from 77 hypertensive and 199 normotensive individuals were analyzed in this study. : The IMTs of the CCA, ICA, and ECA, and the TyG index were all higher in hypertensive individuals compared to the control group (all < 0.05). After controlling for age, sex, the body-mass index, and TyG index, HTN was an independent predictor of a high CCA IMT (odds ratio (OR) = 2.48; 95% confidence interval (CI) = 1.24⁻4.93) and presence of plaque (OR = 2.36; CI = 1.15⁻4.85) in the carotid artery. : HTN was an independent risk of carotid IMT thickening and atherosclerosis. TyG index could only predict the CCA IMT independent of other risk factors (OR = 2.09; CI = 1.07⁻4.09).
高血压(HTN)是心血管疾病的重要危险因素。高血压是动脉粥样硬化的主要原因,可导致心肌梗死和中风。胰岛素抵抗(IR)与高血压和动脉粥样硬化相关。为了确定高血压对颈内动脉(ICA)、颈外动脉(ECA)和颈总动脉(CCA)内膜中层厚度(IMT)影响的差异,并评估高血压个体与血压正常个体之间颈动脉斑块的存在情况,在社区居民中开展了一项病例对照研究。本研究还调查了甘油三酯葡萄糖(TyG)指数与动脉粥样硬化之间的关系。
本研究分析了77例高血压患者和199例血压正常个体的数据。
与对照组相比,高血压个体的CCA、ICA和ECA的IMT以及TyG指数均更高(均P<0.05)。在控制年龄、性别、体重指数和TyG指数后,高血压是颈动脉CCA-IMT升高(比值比(OR)=2.48;95%置信区间(CI)=1.24⁻4.93)和斑块存在(OR = 2.36;CI = 1.15⁻4.85)的独立预测因素。
高血压是颈动脉IMT增厚和动脉粥样硬化的独立危险因素。TyG指数仅能独立于其他危险因素预测CCA-IMT(OR = 2.09;CI = 1.07⁻4.09)。