Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Department for Movement and Clinical Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Elife. 2018 Oct 22;7:e33977. doi: 10.7554/eLife.33977.
Distinct anatomical and spectral channels are thought to play specialized roles in the communication within cortical networks. While activity in the alpha and beta frequency range (7 - 40 Hz) is thought to predominantly originate from infragranular cortical layers conveying feedback-related information, activity in the gamma range (>40 Hz) dominates in supragranular layers communicating feedforward signals. We leveraged high precision MEG to test this proposal, directly and non-invasively, in human participants performing visually cued actions. We found that visual alpha mapped onto deep cortical laminae, whereas visual gamma predominantly occurred more superficially. This lamina-specificity was echoed in movement-related sensorimotor beta and gamma activity. These lamina-specific pre- and post- movement changes in sensorimotor beta and gamma activity suggest a more complex functional role than the proposed feedback and feedforward communication in sensory cortex. Distinct frequency channels thus operate in a lamina-specific manner across cortex, but may fulfill distinct functional roles in sensory and motor processes.
不同的解剖和频谱通道被认为在皮质网络内的通信中发挥专门作用。虽然 alpha 和 beta 频带（7-40 Hz）的活动被认为主要源自传递反馈相关信息的下颗粒皮质层，而 gamma 频带（>40 Hz）的活动则在传递前馈信号的上颗粒层中占主导地位。我们利用高精度 MEG 在执行视觉提示动作的人类参与者中直接和非侵入性地检验了这一假设。我们发现，视觉 alpha 映射到深层皮质层，而视觉 gamma 则主要出现在浅层。这种层特异性在与运动相关的感觉运动 beta 和 gamma 活动中得到了呼应。感觉运动 beta 和 gamma 活动在运动前和运动后的这种层特异性变化表明，其在感觉皮层中的功能作用比反馈和前馈通信的提议更为复杂。因此，不同的频率通道以层特异性的方式在整个皮层中运作，但在感觉和运动过程中可能具有不同的功能作用。
