Poynard T, Delfraissy J F, Naveau S, Dubreuil P, Gut J P, Raskine L, Grangeot-Keros L, Pillot J, Chaput J C
Gastroenterol Clin Biol. 1987 Apr;11(4):283-7.
In the absence of a specific marker, the observed prevalence of so called non-A non-B hepatitis depends on the sensitivity of the markers of the other viral infections known to induce hepatitis. We have reevaluated this prevalence after using sensitive markers of HBV (HBs monoclonal radioimmunoassay M-RIA and IgM anti-HBc), EBV (IgM anti-VCA), CMV (IgM anti-CMV) and HSV (IgM anti-HSV) in a group of 53 subjects usually considered as having acute or chronic hepatitis. Detection of IgM against HBc, CMV and HSV used immunocapture tests. Among the 37 patients with acute hepatitis, 11 (30 p. 100) were positive for at least one sensitive marker, including 10 markers of HBV (7 M-RIA and 3 IgM anti-HBc) and one IgM anti-CMV. Among the 16 patients with chronic hepatitis, one was positive for HBV by M-RIA; five patients had a false positive reaction to EBV (IgM anti-VCA) disappearing when rheumatoid factor was eliminated. This study shows that many cases of the so-called non-A non-B hepatitis are in fact due to HBV or to a variant of HBV. Definition of non-A non-B hepatitis must include subjects negative for HBV by M-RIA and IgM anti-HBc and negative for CMV by IgM anti-CMV.
在缺乏特异性标志物的情况下，所谓非甲非乙型肝炎的观察患病率取决于已知可诱发肝炎的其他病毒感染标志物的敏感性。我们在一组通常被认为患有急性或慢性肝炎的53名受试者中，使用了乙肝病毒（HBs单克隆放射免疫测定法M-RIA和IgM抗-HBc）、EB病毒（IgM抗-VCA）、巨细胞病毒（IgM抗-CMV）和单纯疱疹病毒（IgM抗-HSV）的敏感标志物后，重新评估了这一患病率。针对HBc、CMV和HSV的IgM检测采用免疫捕获试验。在37例急性肝炎患者中，11例（30%）至少有一种敏感标志物呈阳性，其中包括10例乙肝病毒标志物（7例M-RIA和3例IgM抗-HBc）和1例IgM抗-CMV。在16例慢性肝炎患者中，1例M-RIA检测乙肝病毒呈阳性；5例患者对EB病毒（IgM抗-VCA）有假阳性反应，在消除类风湿因子后消失。这项研究表明，许多所谓的非甲非乙型肝炎病例实际上是由乙肝病毒或乙肝病毒变异体引起的。非甲非乙型肝炎的定义必须包括M-RIA检测乙肝病毒阴性、IgM抗-HBc阴性且IgM抗-CMV检测巨细胞病毒阴性的受试者。
