Wei Fang, Liao Xiao-Fang, Liu Xiao-Fei, Yang Mei-Hua, Lu Jing-Hua, Kong Wei-Jun
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
College of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China.
Zhongguo Zhong Yao Za Zhi. 2018 Sep;43(17):3431-3443. doi: 10.19540/j.cnki.cjcmm.20180529.001.
In the processes of planting, harvest, transport and storage, improper treatment of Chinese materia medica (CMM) and foodstuffs and agricultural products will result in fungal growth and mycotoxins contamination, which will not only directly affect the quality, safety and efficacy of these complex matrices, but also seriously threaten the consumers' health and lives. Therefore, the establishment of high-throughout analytical methods with high sensitivity for the determination of mycotoxins in CMM and foodstuffs and agricultural products at trace levels will provide reliable references for reducing the risk of mycotoxin exposure in humans. Due to the matrix complexity of CMM and foodstuffs and agricultural products, highly-effective pretreatment technologies are necessary for the establishment of such analytical techniques. In this review, the current extraction and purification methods commonly used for the detection of mycotoxins were summarized, the importance of pretreatment techniques for the precise quantification of mycotoxins in complex matrices such as Chinese herbal medicines was highlighted, as well as the development tendency about the pretreatment techniques for mycotoxins in complex matrices in the future was proposed.
在中药材、食品及农产品的种植、收获、运输和储存过程中，对其处理不当会导致真菌生长和霉菌毒素污染，这不仅会直接影响这些复杂基质的质量、安全性和功效，还会严重威胁消费者的健康和生命。因此，建立高灵敏度的高通量分析方法以测定中药材、食品及农产品中痕量霉菌毒素，将为降低人类霉菌毒素暴露风险提供可靠参考。由于中药材、食品及农产品的基质复杂性，建立此类分析技术需要高效的预处理技术。本文综述了目前常用于检测霉菌毒素的提取和净化方法，强调了预处理技术对精确量化中药材等复杂基质中霉菌毒素的重要性，并提出了未来复杂基质中霉菌毒素预处理技术的发展趋势。
