Finocchario-Kessler Sarah, Goggin Kathy, Staggs Vince, Wanyenze Rhoda K, Beyeza-Kashesya Jolly, Mindry Deborah, Birungi Josephine, Wagner Glenn J
Department of Family Medicine, University of Kansas Medical Center, Kansas City, USA.
Health Services and Outcomes Research, Children's Mercy Kansas City, Kansas City, USA.
BMC Res Notes. 2018 Oct 22;11(1):753. doi: 10.1186/s13104-018-3857-9.
Data on early miscarriage incidence is limited due to various social and methodological barriers. We report on 24-month pregnancy outcomes of 299 female Ugandan HIV clients in committed relationships with an intention to conceive. Miscarriage data are reported as auxiliary findings to a larger study (5R01HD072633).
127 (42%) participants reported a pregnancy during the study; among the remaining 172, 82 indicated they stopped trying to conceive, and 16 dropped out prior to month 24. Of the 127 pregnancies, 55 (43%) resulted in live births, 67 (53%) in spontaneous miscarriage, 1 (< 1%) in stillbirth, 1 (< 1%) in abortion, and 3 (2%) in unknown outcomes. Three-quarters (75%) of miscarriages for which time until miscarriage was available were reported to occur in the first trimester (mean = 11.3 weeks gestation). The 67 participants who reported a miscarriage tended to be older (mean 33 vs. 30 years), but the significance of age did not persist after adjusting for multiple tests. We observed relatively low rates of pregnancy and high rates of miscarriage among this cohort of HIV-positive women wanting to conceive. Rigorously designed studies are needed to better understand the observed high rate of early miscarriage among HIV-infected women.
由于各种社会和方法学障碍，早期流产发生率的数据有限。我们报告了299名处于稳定恋爱关系且有怀孕意愿的乌干达感染艾滋病毒女性的24个月妊娠结局。流产数据作为一项更大规模研究（5R01HD072633）的辅助结果进行报告。
127名（42%）参与者在研究期间报告怀孕；在其余172名中，82名表示停止尝试怀孕，16名在第24个月之前退出。在这127次怀孕中，55次（43%）为活产，67次（53%）为自然流产，1次（<1%）为死产，1次（<1%）为人工流产，3次（2%）结局不明。在已知流产时间的流产案例中，四分之三（75%）报告发生在孕早期（平均妊娠11.3周）。报告流产的67名参与者年龄往往较大（平均33岁对30岁），但在进行多次检验校正后，年龄的显著性不再存在。我们观察到，在这一想要怀孕的艾滋病毒阳性女性队列中，怀孕率相对较低，流产率较高。需要进行严格设计的研究，以更好地理解在感染艾滋病毒的女性中观察到的高早期流产率。
