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粒细胞-巨噬细胞集落刺激因子。1,25-二羟维生素D3对正常人外周血淋巴细胞的敏感且受受体介导的调节作用。

Granulocyte-macrophage colony-stimulating factor. Sensitive and receptor-mediated regulation by 1,25-dihydroxyvitamin D3 in normal human peripheral blood lymphocytes.

作者信息

Tobler A, Gasson J, Reichel H, Norman A W, Koeffler H P

出版信息

J Clin Invest. 1987 Jun;79(6):1700-5. doi: 10.1172/JCI113009.

DOI:10.1172/JCI113009
PMID:3034980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC424508/
Abstract

We show that 1,25-dihydroxyvitamin D3 (1,25[OH]2D3), the most hormonally active metabolite of vitamin D3, modulates sensitively and specifically both the protein and messenger RNA accumulation of the multilineage growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF). The regulation of GM-CSF expression is seen in both normal human mitogen-activated T lymphocytes and T lymphocytes from a line (S-LB1) transformed with human T cell lymphotropic virus 1 (HTLV-1). In contrast, cells from a HTLV-1 transformed T lymphocyte line (Ab-VDR) established from a patient with vitamin D-resistant rickets type II with undetectable 1,25(OH)2D3 cellular receptors are resistant to the action of 1,25(OH)2D3. Inhibition of GM-CSF expression by 1,25(OH)2D3 can occur independently of interleukin 2 regulation and is probably mediated through cellular 1,25(OH)2D3 receptors. We conclude that 1,25(OH)2D3 may be important in the physiology of hematopoiesis.

摘要

我们发现，维生素D3的最具激素活性的代谢产物1,25-二羟基维生素D3（1,25[OH]2D3）能灵敏且特异地调节多谱系生长因子粒细胞-巨噬细胞集落刺激因子（GM-CSF）的蛋白质和信使核糖核酸积累。在正常人的有丝分裂原激活的T淋巴细胞以及用人嗜T细胞病毒1（HTLV-1）转化的T淋巴细胞系（S-LB1）的T淋巴细胞中均可见到GM-CSF表达的调节。相比之下，从一名患有II型维生素D抵抗性佝偻病且细胞内1,25(OH)2D3受体检测不到的患者建立的HTLV-1转化的T淋巴细胞系（Ab-VDR）的细胞对1,25(OH)2D3的作用具有抗性。1,25(OH)2D3对GM-CSF表达的抑制可独立于白细胞介素2调节而发生，并且可能是通过细胞内1,25(OH)2D3受体介导的。我们得出结论，1,25(OH)2D3可能在造血生理学中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/4541ea24cb1c/jcinvest00117-0165-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/6856b5b72a18/jcinvest00117-0163-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/519c27739528/jcinvest00117-0163-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/47710741044c/jcinvest00117-0163-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/b2353e0401d7/jcinvest00117-0164-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/f9d532ea837d/jcinvest00117-0164-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/31d21fa0d046/jcinvest00117-0164-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/8b114ec40002/jcinvest00117-0165-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/51991738563e/jcinvest00117-0165-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/4541ea24cb1c/jcinvest00117-0165-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/6856b5b72a18/jcinvest00117-0163-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/519c27739528/jcinvest00117-0163-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/47710741044c/jcinvest00117-0163-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/b2353e0401d7/jcinvest00117-0164-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/f9d532ea837d/jcinvest00117-0164-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/31d21fa0d046/jcinvest00117-0164-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/8b114ec40002/jcinvest00117-0165-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/51991738563e/jcinvest00117-0165-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8188/424508/4541ea24cb1c/jcinvest00117-0165-c.jpg

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