强直性脊柱炎的系列研究。肺炎克雷伯菌与活动性疾病的关联。
Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease.
作者信息
Ebringer R W, Cawdell D R, Cowling P, Ebringer A
出版信息
Ann Rheum Dis. 1978 Apr;37(2):146-51. doi: 10.1136/ard.37.2.146.
Abstract
A study of 163 patients with ankylosing spondylitis seen on 433 occasions showed that active inflammatory disease was strongly associated with the presence of Klebsiella pneumoniae in the faeces (P less than 0.001). Sequential studies showed that in patients with inactive disease the presence of a positive culture for Klebsiella was associated with the subsequent development of active inflammatory disease (P less than 0.001). These findings support the hypothesis that Kl. pneumoniae may be an initiating agent in ankylosing spondylitis.
摘要
一项对163例强直性脊柱炎患者进行433次观察的研究表明，活动性炎性疾病与粪便中肺炎克雷伯菌的存在密切相关（P<0.001）。连续研究表明，在非活动性疾病患者中，肺炎克雷伯菌培养阳性与随后活动性炎性疾病的发生相关（P<0.001）。这些发现支持了肺炎克雷伯菌可能是强直性脊柱炎起始因素的假说。
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