Palmer A E
J Med Primatol. 1987;16(2):99-130.
Between 1932 and 1972, 24 known infections of man by B virus caused 23 cases of encephalitis and 18 fatalities. The virus has been isolated from dermal lesions and neural ganglia from macaque monkeys. Serological evidence of infection is complicated by close antigenic relationships between B virus, Herpesvirus simplex, and SA8. Hyperimmune globulin produced from monkey, horse, and rabbit sera has not proved highly effective. Formalin-inactivated vaccine appears safe and antigenic in man but has not been licensed. Half of all human subjects have neutralizing B virus antibody related to their H. simplex titer. More stable animal populations and the improved use of protective apparel have reduced, but not eliminated, the risk of B virus to man.
1932年至1972年间，已知有24例人类感染B病毒，导致23例脑炎和18例死亡。该病毒已从猕猴的皮肤损伤和神经节中分离出来。由于B病毒、单纯疱疹病毒和SA8之间存在密切的抗原关系，感染的血清学证据较为复杂。用猴、马和兔血清制备的高效价免疫球蛋白尚未证明有高效。福尔马林灭活疫苗在人体中似乎是安全且有抗原性的，但尚未获得许可。所有人类受试者中有一半具有与单纯疱疹病毒滴度相关的中和B病毒抗体。更稳定的动物种群以及防护服装的更好使用降低了但并未消除B病毒对人类的风险。
