Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, PR China.
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, PR China.
Fitoterapia. 2018 Nov;131:55-58. doi: 10.1016/j.fitote.2018.10.022. Epub 2018 Oct 22.
Two novel sesquiterpenoids with an unprecedented tricyclo[4,4,2,1]hendecane scaffold, namely emericellins A (1) and B (2) representing a new skeleton, were isolated from the liquid cultures of an endophytic fungus Emericella sp. XL 029 associated with the leaves of Panax notoginseng. Their structures and relative configurations were characterized by extensive spectroscopic methods. Compounds 1-2 displayed moderate activities against three fungal strains (Verticillium dahliae Kleb, Helminthosporium maydis, and Botryosphaeria dothidea) and three bacterial strains (Bacillus subtilis, Bacillus cereus and Escherichia coli) with MIC values of 25-50 μg/mL.
从与三七叶片共生的内生真菌埃默里菌 XL029 的液体培养物中分离得到了两种新型倍半萜类化合物 1 和 2，具有前所未有的三环[4,4,2,1]十一烷骨架，分别代表一种新骨架。通过广泛的光谱方法确定了它们的结构和相对构型。化合物 1-2 对 3 种真菌（黄萎病菌、玉米弯孢霉和地衣葡萄孢菌）和 3 种细菌（枯草芽孢杆菌、蜡样芽孢杆菌和大肠杆菌）显示出中等的活性，MIC 值为 25-50μg/mL。
