神经生长因子缺乏会导致体外潜伏性单纯疱疹病毒重新激活。
Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro.
作者信息
Wilcox C L, Johnson E M
出版信息
J Virol. 1987 Jul;61(7):2311-5. doi: 10.1128/JVI.61.7.2311-2315.1987.
Abstract
Primary sympathetic neuronal cultures were maintained for up to 5 weeks after inoculation with herpes simplex virus (HSV) without evidence of viral infection. Upon deprivation of nerve growth factor, the cultures produced infectious HSV, indicating that the cultures harbored latent HSV. This study demonstrates a function of nerve growth factor in the maintenance of HSV latency.
摘要
原代交感神经元培养物在接种单纯疱疹病毒（HSV）后维持长达5周，未出现病毒感染迹象。在剥夺神经生长因子后，培养物产生了具有传染性的HSV，这表明培养物中存在潜伏性HSV。本研究证明了神经生长因子在维持HSV潜伏状态中的作用。
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