The Reproductive Medical Center, The Seventh Affiliated Hospital, Sun Yat-sen University, No.628, Zhenyuan Rd, Shenzhen, 518107, China.
Department of Thoracic Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, No.628, Zhenyuan Rd, Shenzhen, 518107, China.
BMC Public Health. 2023 Nov 8;23(1):2195. doi: 10.1186/s12889-023-16793-3.
Many countries and regions have experienced male fertility problems due to various influencing factors, especially in less developed countries. Unlike female infertility, male infertility receives insufficient attention. Understanding the changing patterns of male infertility in the world, different regions and different countries is crucial for assessing the global male fertility and reproductive health.
We obtained data on prevalence, years of life lived with disability (YLD), age-standardized rates of prevalence (ASPR) and age-standardized YLD rate (ASYR) from the Global Burden of Disease Study 2019. We analyzed the burden of male infertility at all levels, including global, regional, national, age stratification and Socio-demographic Index (SDI).
In 2019, the global prevalence of male infertility was estimated to be 56,530.4 thousand (95% UI: 31,861.5-90,211.7), reflecting a substantial 76.9% increase since 1990. Furthermore, the global ASPR stood at 1,402.98 (95% UI: 792.24-2,242.45) per 100,000 population in 2019, representing a 19% increase compared to 1990. The regions with the highest ASPR and ASYR for male infertility in 2019 were Western Sub-Saharan Africa, Eastern Europe, and East Asia. Notably, the prevalence and YLD related to male infertility peaked in the 30-34 year age group worldwide. Additionally, the burden of male infertility in the High-middle SDI and Middle SDI regions exceeded the global average in terms of both ASPR and ASYR.
The global burden of male infertility has exhibited a steady increase from 1990 to 2019, as evidenced by the rising trends in ASPR and ASYR, particularly in the High-middle and Middle SDI regions. Notably, the burden of male infertility in these regions far exceeds the global average. Additionally, since 2010, there has been a notable upward trend in the burden of male infertility in Low and Middle-low SDI regions. Given these findings, it is imperative to prioritize efforts aimed at improving male fertility and reproductive health.
许多国家和地区都受到各种因素的影响，出现了男性生育力问题，尤其是在欠发达国家。与女性不孕不同，男性不育症没有得到足够的重视。了解世界、不同地区和不同国家男性不育症的变化模式，对于评估全球男性生育力和生殖健康至关重要。
我们从 2019 年全球疾病负担研究中获得了患病率、残疾生存年（YLD）、年龄标准化患病率（ASPR）和年龄标准化 YLD 率（ASYR）的数据。我们分析了男性不育症在全球、区域、国家、年龄分层和社会人口指数（SDI）各级别的负担。
2019 年，全球男性不育症的患病率估计为 56530.4 千例（95%UI：31861.5-90211.7），自 1990 年以来增长了 76.9%。此外，2019 年全球 ASPR 为每 100000 人 1402.98（95%UI：792.24-2242.45），与 1990 年相比增长了 19%。2019 年，男性不育症 ASPR 和 ASYR 最高的地区是撒哈拉以南非洲西部、东欧和东亚。值得注意的是，全球范围内，30-34 岁年龄组的男性不育症患病率和 YLD 最高。此外，高、中社会人口指数地区的男性不育症负担在 ASPR 和 ASYR 方面均超过全球平均水平。
从 1990 年到 2019 年，全球男性不育症的负担呈稳步上升趋势，ASPR 和 ASYR 的上升趋势表明了这一点，尤其是在高、中社会人口指数地区。值得注意的是，这些地区的男性不育症负担远远超过全球平均水平。此外，自 2010 年以来，中、低社会人口指数地区男性不育症负担呈明显上升趋势。鉴于这些发现，优先努力改善男性生育力和生殖健康至关重要。
