Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan.
Germark Biotechnology Co., Ltd., Taichung, Taiwan.
Sci Rep. 2018 Oct 23;8(1):15625. doi: 10.1038/s41598-018-33893-y.
Diet and exercise are conventional methods for controlling body weight and are linked to alterations in gut microbiota. However, the associations of diet, exercise, and gut microbiota in the control of obesity remain largely unknown. In the present study, using 16S rRNA amplicon sequencing and fecal microbiota transplantation (FMT), normal fat diet (NFD), exercise and their combination resulted in improved metabolic profiles in comparison to sedentary lifestyle with high fat diet (HFD). Moreover, diet exerted more influence than exercise in shaping the gut microbiota. HFD-fed mice receiving FMT from NFD-exercised donors not only showed remarkably reduced food efficacy, but also mitigated metabolic profiles (p < 0.05). The transmissible beneficial effects of FMT were associated with bacterial genera Helicobacter, Odoribacter and AF12 and overrepresentation of oxidative phosphorylation and glycolysis genes. Our findings demonstrate that the beneficial effects of diet and exercise are transmissible via FMT, suggesting a potential therapeutic treatment for obesity.
饮食和运动是控制体重的常规方法，与肠道微生物群的改变有关。然而，饮食、运动和肠道微生物群在肥胖控制中的关联在很大程度上尚不清楚。在本研究中，使用 16S rRNA 扩增子测序和粪便微生物群移植 (FMT)，与高脂肪饮食（HFD）结合的安静生活方式相比，正常脂肪饮食（NFD）、运动及其组合导致代谢特征得到改善。此外，饮食对肠道微生物群的影响大于运动。从 NFD 运动供体接受 FMT 的 HFD 喂养的小鼠不仅显示出食物效率显著降低，而且还减轻了代谢特征（p<0.05）。FMT 的可传播有益效果与细菌属 Helicobacter、Odoribacter 和 AF12 以及氧化磷酸化和糖酵解基因的过度表达有关。我们的研究结果表明，饮食和运动的有益效果可以通过 FMT 传递，这为肥胖症的潜在治疗提供了一种可能的治疗方法。
