The Department of Internal Medicine, Kyushu University Beppu Hospital, 4546 Tsurumihara, Beppu, Oita, 874-0838, Japan.
Mol Cell Biochem. 2019 May;455(1-2):1-5. doi: 10.1007/s11010-018-3465-y. Epub 2018 Oct 23.
Somatic telomere DNA length is known to shorten with certain disease states and senescence. Furthermore, we have reported that the telomere length of a sub-healthy population also correlates with the blood data of laboratory tests. These facts suggest that patients with shorter telomere length tend to be hospitalized more easily than patients with longer telomere length. And such hospitalization tendencies can also be reflected in differences in clinical laboratory data. To address this issue, we evaluated and compared the telomere length and clinical laboratory data of outpatients and inpatients. In this study, 35 inpatients with chronic illness and 38 outpatients with one or more weeks without hospitalization experience were enrolled. Telomere length was shorter in hospitalized patients than outpatients. Inpatients and outpatients showed significant differences in some laboratory test results. Male outpatients showed higher values of fast blood sugar, HbA1c, blood urea nitrogen, creatinine, C-reactive protein, red blood cell count, and hemoglobin. Among female outpatients, the values of aspartate aminotransferase, alanine aminotransferase, albumin, creatine kinase, red blood cell count and hemoglobin were high. Of these, only albumin levels showed a positive correlation with telomere length in both sexes. Unexpectedly, all the other clinical data distinguishing outpatients and inpatients showed no significant association with telomere length. These items appeared to be related to hospital risk independently of TL. Having a shorter somatic telomere length appeared to be at a higher risk of hospitalization. This risk can be augmented by further complications such as deterioration of nutritional status and anemia. Maintaining sufficiently high nutritional status and erythropoietic potential may lead to avoidance of clinical events that require hospitalization.
体细胞端粒 DNA 长度已知会随着某些疾病状态和衰老而缩短。此外，我们已经报道称，亚健康人群的端粒长度也与实验室检测的血液数据相关。这些事实表明，端粒较短的患者比端粒较长的患者更容易住院。这种住院趋势也可以反映在临床实验室数据的差异上。为了解决这个问题，我们评估并比较了门诊患者和住院患者的端粒长度和临床实验室数据。在这项研究中，纳入了 35 名患有慢性疾病的住院患者和 38 名有 1 周以上无住院经历的门诊患者。与门诊患者相比，住院患者的端粒长度更短。门诊患者和住院患者的一些实验室检测结果存在显著差异。男性门诊患者的快速血糖、HbA1c、血尿素氮、肌酐、C 反应蛋白、红细胞计数和血红蛋白值较高。在女性门诊患者中，天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、白蛋白、肌酸激酶、红细胞计数和血红蛋白值较高。在这些指标中，只有白蛋白水平在男女两性中均与端粒长度呈正相关。出乎意料的是，区分门诊患者和住院患者的所有其他临床数据与端粒长度均无显著关联。这些项目似乎与 TL 无关，与住院风险独立相关。体细胞端粒较短似乎与住院风险增加有关。这种风险可能会因营养状况恶化和贫血等进一步并发症而加剧。保持足够高的营养状态和红细胞生成潜能可能会避免需要住院的临床事件。
