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美国经导管主动脉瓣置换术与外科主动脉瓣置换术后的住院时间和出院去向。

Length of Stay and Discharge Disposition After Transcatheter Versus Surgical Aortic Valve Replacement in the United States.

机构信息

Division of Cardiology (S.A., C.J.R., M.A.C., J.S.R., J.P.V.), University of North Carolina, Chapel Hill.

Division of Epidemiology, Gillings School of Public Health (S.A., P.D.S.), University of North Carolina, Chapel Hill.

出版信息

Circ Cardiovasc Interv. 2018 Sep;11(9):e006929. doi: 10.1161/CIRCINTERVENTIONS.118.006929.

Abstract

BACKGROUND

As transcatheter aortic valve replacement (TAVR) extends its reach to lower surgical risk patients, the differences between resource utilization for TAVR and surgical AVR (SAVR) will become increasingly important.

METHODS AND RESULTS

AVR procedures between January 2012 and September 2015 at hospitals performing TAVR were identified using the National Inpatient Sample databases. Adults aged ≥50 years with aortic stenosis who underwent isolated TAVR or SAVR were eligible for inclusion. Standardized morbidity ratio weights were calculated using patient demographics, comorbidities, and hospital characteristics. Weighted linear and generalized logistic regression models were used to estimate the effect of undergoing TAVR, compared with undergoing SAVR, on length of stay (LOS) and discharge disposition. In TAVR-performing hospitals, 7266 (40%) patients underwent TAVR (6107 endovascular approach and 1159 transapical approach), while 10 833 (60%) underwent isolated SAVR. Patients undergoing TAVR were older, more likely to be female, and had more comorbidities. From 2012 to 2015, average LOS declined for both TAVR (6.3 days to 4.6 days; P<0.0001) and SAVR (7.5 days to 6.8 days; P<0.0001), with greater reduction in the TAVR group ( P<0.0001). An increase in home/home health discharge was noted with TAVR (67.7%-77.4%; P<0.0001) but not with SAVR (76.8%-79.5%; P=0.25). After standardizing, patients undergoing TAVR had significantly shorter LOS (change in estimate, -2.93, 95% CI, -3.26 to -2.60) and lower incidence of transfer to skilled nursing facility (odds ratio, 0.45; 95% CI, 0.40-0.51) but no difference in in-hospital mortality (odds ratio, 0.85; 95% CI, 0.61-1.20) compared with if they had undergone SAVR. As compared with SAVR, patients who had TAVR performed via an endovascular approach had shorter LOS and lower rates of skilled nursing facility transfer, whereas in the transapical cohort, LOS, and skilled nursing facility transfer were similar to SAVR.

CONCLUSIONS

As compared with if they undergo SAVR, patients undergoing TAVR (by a nontransapical approach) had a shorter LOS and higher likelihood of home discharge, as opposed to skilled nursing facility. From 2012 to 2015, there was a greater trend towards a reduction of LOS and more home discharges among TAVR, as opposed to SAVR. These data have important implications in the era of constrained resources with a growing emphasis on reducing health care costs.

摘要

背景

随着经导管主动脉瓣置换术(TAVR)应用于低手术风险患者,TAVR 和外科主动脉瓣置换术(SAVR)之间资源利用的差异将变得越来越重要。

方法和结果

使用国家住院患者样本数据库,确定了 2012 年 1 月至 2015 年 9 月期间在开展 TAVR 的医院进行的 AVR 手术。符合条件的患者为年龄≥50 岁、患有主动脉瓣狭窄、单独接受 TAVR 或 SAVR 的患者。使用患者人口统计学、合并症和医院特征计算标准化发病率比权重。使用加权线性和广义逻辑回归模型来估计与 SAVR 相比,行 TAVR 对住院时间(LOS)和出院去向的影响。在开展 TAVR 的医院中,7266 名(40%)患者接受了 TAVR(6107 名经血管途径,1159 名经心尖途径),10833 名(60%)患者接受了单纯 SAVR。行 TAVR 的患者年龄更大,更可能为女性,且合并症更多。从 2012 年到 2015 年,TAVR(6.3 天至 4.6 天;P<0.0001)和 SAVR(7.5 天至 6.8 天;P<0.0001)的平均 LOS 均有所下降,TAVR 组降幅更大(P<0.0001)。TAVR 组出院至家庭/家庭健康的比例增加(67.7%-77.4%;P<0.0001),而 SAVR 组无明显变化(76.8%-79.5%;P=0.25)。标准化后,行 TAVR 的患者 LOS 明显缩短(估计差值,-2.93,95%CI,-3.26 至-2.60),转至护理院的发生率降低(比值比,0.45;95%CI,0.40-0.51),但院内死亡率无差异(比值比,0.85;95%CI,0.61-1.20),与行 SAVR 相比。与 SAVR 相比,行经血管 TAVR 的患者 LOS 更短,转至护理院的比例更低,而在心尖途径 TAVR 组中,LOS 和转至护理院的比例与 SAVR 相似。

结论

与 SAVR 相比,行 TAVR(非经心尖途径)的患者 LOS 更短,出院至家庭的可能性更高,而非护理院。从 2012 年到 2015 年,TAVR 组的 LOS 更短,出院至家庭的比例更高,而 SAVR 组无明显变化。在资源有限且越来越重视降低医疗成本的时代,这些数据具有重要意义。

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