Research Center for Energy Convergence Technology, Pusan National University, Busan, South Korea.
Department of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan, South Korea.
Adv Exp Med Biol. 2018;1078:103-117. doi: 10.1007/978-981-13-0950-2_6.
Tissues are often damaged by physical trauma, infection or tumors. A slight injury heals naturally through the normal healing process, while severe injury causes serious health implications. Therefore, many efforts have been devoted to treat and repair various tissue defects. Recently, tissue engineering approaches have attracted a rapidly growing interest in biomedical fields to promote and enhance healing and regeneration of large-scale tissue defects. On the other hand, with the recent advances in nanoscience and nanotechnology, various nanomaterials have been suggested as novel biomaterials. Graphene, a two-dimensional atomic layer of graphite, and its derivatives have recently been found to possess promoting effects on various types of cells. In addition, their unique properties, such as outstanding mechanical and biological properties, allow them to be a promising option for hard tissue regeneration. Herein, we summarized recent research advances in graphene-based nanocomposites for hard tissue regeneration, and highlighted their promising potentials in biomedical and tissue engineering.
组织常常会因物理创伤、感染或肿瘤而受损。轻微的损伤会通过正常的愈合过程自然治愈，而严重的损伤则会导致严重的健康问题。因此，人们付出了很多努力来治疗和修复各种组织缺陷。最近，组织工程方法在生物医学领域引起了越来越多的关注，以促进和增强大规模组织缺陷的愈合和再生。另一方面，随着纳米科学和纳米技术的最新进展，各种纳米材料被提议作为新型生物材料。石墨烯是一种二维石墨原子层，其衍生物最近被发现对各种类型的细胞具有促进作用。此外，它们独特的性质，如出色的机械和生物性质，使它们成为硬组织再生的有前途的选择。本文总结了基于石墨烯的纳米复合材料在硬组织再生方面的最新研究进展，并强调了它们在生物医学和组织工程中的应用前景。
