Nizami Mohammed Zahedul Islam, Yin Iris Xiaoxue, Lung Christie Ying Kei, Niu John Yun, Mei May Lei, Chu Chun Hung
Faculty of Dentistry, University of Hong Kong, Hong Kong SAR 999077, China.
Faculty of Dentistry, University of Otago, Dunedin 9054, New Zealand.
Pharmaceutics. 2022 Sep 21;14(10):1997. doi: 10.3390/pharmaceutics14101997.
Graphene is a single-layer two-dimensional carbon-based nanomaterial. It presents as a thin and strong material that has attracted many researchers' attention. This study provides a concise review of the potential application of graphene materials in caries and periodontal disease management. Pristine or functionalized graphene and its derivatives exhibit favorable physicochemical, mechanical, and morphological properties applicable to biomedical applications. They can be activated and functionalized with metal and metal nanoparticles, polymers, and other small molecules to exhibit multi-differentiation activities, antimicrobial activities, and biocompatibility. They were investigated in preventive dentistry and regenerative dentistry. Graphene materials such as graphene oxide inhibit cariogenic microbes such as . They also inhibit periodontal pathogens that are responsible for periodontitis and root canal infection. Graphene-fluorine promotes enamel and dentin mineralization. These materials were also broadly studied in regenerative dental research, such as dental hard and soft tissue regeneration, as well as periodontal tissue and bone regeneration. Graphene oxide-based materials, such as graphene oxide-fibroin, were reported as promising in tissue engineering for their biocompatibility, bioactivity, and ability to enhance cell proliferation properties in periodontal ligament stem cells. Laboratory research showed that graphene can be used exclusively or by incorporating it into existing dental materials. The success of laboratory studies can translate the application of graphene into clinical use.
石墨烯是一种单层二维碳基纳米材料。它呈现为一种薄而坚固的材料，已吸引了众多研究人员的关注。本研究简要综述了石墨烯材料在龋齿和牙周疾病治疗中的潜在应用。原始的或功能化的石墨烯及其衍生物展现出适用于生物医学应用的良好物理化学、机械和形态学特性。它们可以用金属和金属纳米颗粒、聚合物及其他小分子进行活化和功能化，以展现多分化活性、抗菌活性和生物相容性。它们在预防牙科和再生牙科领域得到了研究。诸如氧化石墨烯等石墨烯材料可抑制致龋微生物，如…… 它们还能抑制导致牙周炎和根管感染的牙周病原体。石墨烯 - 氟可促进牙釉质和牙本质矿化。这些材料在再生牙科研究中也得到了广泛研究，如牙齿硬组织和软组织再生，以及牙周组织和骨再生。基于氧化石墨烯的材料，如氧化石墨烯 - 丝素蛋白，因其生物相容性、生物活性以及增强牙周膜干细胞增殖特性的能力，在组织工程领域被报道具有应用前景。实验室研究表明，石墨烯可以单独使用，也可以将其掺入现有的牙科材料中。实验室研究的成功能够将石墨烯的应用转化为临床应用。
