交联生物聚合物在高级药物输送和组织工程应用中的作用
Crosslinking Biopolymers for Advanced Drug Delivery and Tissue Engineering Applications.
机构信息
Department of Biomedical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India.
出版信息
Adv Exp Med Biol. 2018;1078:213-231. doi: 10.1007/978-981-13-0950-2_11.
A popular approach to attaining controlled drug delivery from polymer based systems involves the use of cross-linkers. In order to improve the properties of polymers specific to their applications, they can be modified by either physical cross-linkers (high pressure, irradiation) or chemical cross-linkers (glutaraldehyde, genipin). This chapter provides an insight into the different types and mechanisms of cross-linking. It reviews the existing drug delivery systems to understand the effects of cross-linking in them. The recent applications of cross-linked polymeric drug delivery and tissue engineering systems are also discussed.
一种从聚合物基体系中实现控制药物释放的常用方法是使用交联剂。为了改善聚合物的特定性能以适应其应用，可通过物理交联剂（高压、辐照）或化学交联剂（戊二醛、京尼平）进行改性。本章深入探讨了不同类型和交联机制。综述了现有的药物传递系统，以了解交联对它们的影响。还讨论了交联聚合物药物传递和组织工程系统的最新应用。
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