Matsuda M, Jona M, Yasui K, Nagashima K
Virus Res. 1987 Apr;7(2):159-68. doi: 10.1016/0168-1702(87)90077-3.
The genome DNA of JC virus Tokyo-1 strain [JCV(Tokyo-1)], a variant oncogenic in rodents, was molecularly cloned directly from the brain of a Japanese patient with progressive multifocal leukoencephalopathy and from tissue culture, and the restriction enzyme cleavage pattern and regulatory sequences were determined. The restriction pattern of the cloned JCV(Tokyo-1) DNA was different from those of JCVs previously reported in the United States and Germany. Also, the arrangement of the regulatory sequence was unique to this strain. Thus JCV(Tokyo-1) can be classified as a new subtype. The relationship between the restriction pattern and the regulatory sequence of JCV(Tokyo-1), and its characteristic oncogenicity, is discussed.
JC病毒东京-1株[JCV(Tokyo-1)]是一种在啮齿动物中具有致癌性的变异株，其基因组DNA是直接从一名患有进行性多灶性白质脑病的日本患者的大脑以及组织培养物中分子克隆得到的，并确定了其限制性内切酶切割图谱和调控序列。克隆的JCV(Tokyo-1) DNA的限制性图谱与先前在美国和德国报道的JCV不同。此外，该毒株的调控序列排列独特。因此，JCV(Tokyo-1)可被归类为一个新亚型。本文讨论了JCV(Tokyo-1)的限制性图谱与调控序列之间的关系及其独特的致癌性。
