1 Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
2 Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland.
Tissue Eng Part A. 2019 Feb;25(3-4):159-171. doi: 10.1089/ten.TEA.2018.0046. Epub 2018 Dec 31.
Successfully treating osteochondral defects involves regenerating both the damaged articular cartilage and the underlying subchondral bone, in addition to the complex interface that separates these tissues. In this study, we demonstrate that a cartilage template, engineered using bone marrow-derived mesenchymal stem cells, can enhance the regeneration of such defects and promote the development of a more mechanically functional repair tissue. We also use a computational mechanobiological model to understand how joint-specific environmental factors, specifically oxygen levels and tissue strains, regulate the conversion of the engineered template into cartilage and bone in vivo.
成功治疗骨软骨缺损不仅需要再生受损的关节软骨和其下的软骨下骨，还需要再生分隔这些组织的复杂界面。在这项研究中，我们证明了使用骨髓间充质干细胞构建的软骨模板可以增强此类缺损的再生，并促进更具机械功能的修复组织的形成。我们还使用计算力学生物学模型来了解关节特异性环境因素（特别是氧水平和组织应变）如何调节体内工程化模板向软骨和骨的转化。
