[COMPREHENSIVE STUDY OF ANTI-FUNGAL EFFECT OF EVGENOL EMULSION IN POLYSORBAT-80 ON REFERENCE STRAIN OF CANDIDA ALBICANS ATCC 885-653].

The aim of this research was a comprehensive study of the polysorbate - 80 emulsified eugenol effect on the culture of Candida albicans ATCC 885-653 by determining of minimal mycostatic, mycocidal concentrations and indexes of fungi reproduction intensity in postmycostatic eugenol concentrations. Minimal mycostatic and mycocidal concentrations was determined by sequentialmakrodilution of eugenol emulsion in Sabouraud liquid medium with next transferringthe tubes' contents on the solid Sabouraud medium. The amount of colony forming units /ml of Candida albicans ATCC 885-653 was determined by the sector method. The high antifungal activity of the eugenol emulsion in polysorbate-80 for the Candida albicans ATCC 885-653 culture has been proven. However, postmicostatic concentrations of eugenol led to increasing the number of colony-forming units per 1ml 10 times compared with control, it can promoteincreasingthe colonization potential offungi in this range of concentrations.