MD/PhD Combined Degree Program and The Neuroscience Graduate Program.
Department of Cell Biology, Neuroscience and Anatomy.
Curr Opin Neurol. 2018 Dec;31(6):709-717. doi: 10.1097/WCO.0000000000000613.
The underlying mechanisms responsible for chronic and progressive neurological damage after traumatic brain injury (TBI) are poorly understood, and therefore, current treatment options are limited. Proteomics is an emerging methodology to study changes to the TBI proteome in both patients and experimental models.
Although experimentally complex, mass spectrometry-based proteomics approaches are converging on a set of common methods. However, these methods are being applied to an increasingly diverse range of experimental models and types of injury.
In this review, our aim is to briefly describe experimental TBI models and the underlying methods common to most proteomic approaches. We will then review a series of articles that have recently appeared in which these approaches have been applied to important TBI questions. We will summarize several recent experimental studies, and suggest how the results of these emerging studies might impact future research as well as patient treatment.
颅脑损伤 (TBI) 后慢性和进行性神经损伤的潜在机制尚不清楚，因此，目前的治疗选择有限。蛋白质组学是一种新兴的方法，可用于研究患者和实验模型中 TBI 蛋白质组的变化。
尽管实验复杂，但基于质谱的蛋白质组学方法正在趋于一组共同的方法。然而，这些方法正在被应用于越来越多样化的实验模型和损伤类型。
在这篇综述中，我们的目的是简要描述实验性 TBI 模型和大多数蛋白质组学方法所共有的基本方法。然后，我们将回顾最近发表的一系列文章，这些文章应用这些方法来解决重要的 TBI 问题。我们将总结几项最近的实验研究，并提出这些新兴研究的结果如何影响未来的研究以及患者的治疗。
