载银纳米抗菌玻璃陶瓷涂层氧化锆的抗菌活性和成纤维细胞活力。
Antibacterial Activity and Fibroblast Cell Viability of Zirconia Coated with Glass Ceramic Containing Ag and NaF Nanoparticles.
机构信息
RIS Foundation for Advanced Biomaterials, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea.
Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju, 61186, Republic of Korea.
出版信息
J Nanosci Nanotechnol. 2019 Feb 1;19(2):1035-1037. doi: 10.1166/jnn.2019.15914.
The aim of this study was to evaluate the antibacterial activity against and fibroblast viability of zirconia coated with glass ceramic powder containing Ag and F nanoparticles. Specimens were divided into eight groups depending on the glass ceramic powders: 5, 10, 15, 20 wt% of NaF and Ag, respectively. Adhesion of on glass-coated zirconia surface was evaluated by antimicrobial test. Fibroblast viability was examined by WST-8 assay. In result, the bacterial activity was reduced by 11.8%, 15.4% in Ag 10 wt% and 20 wt% groups. When 515 wt% of NaF was added, bacterial counts decreased to 4.265.4%, and when 20 wt% of NaF was added, the number of bacteria increased by 29.4%. Regardless of Ag and NaF content, all zirconia specimens showed cell viability above 70%. Within the limitations of this study, zirconia coated with glass ceramics powder containing Ag and NaF was found to reduce the adhesion of but had no influence on osteoblast activation.
本研究旨在评估含 Ag 和 F 纳米颗粒的玻璃陶瓷粉末涂覆氧化锆的抗菌活性和成纤维细胞活力。根据玻璃陶瓷粉末的不同，将标本分为 8 组：分别为 5wt%、10wt%、15wt%、20wt%的 NaF 和 Ag。通过抗菌试验评估 对玻璃涂覆氧化锆表面的黏附。通过 WST-8 测定法检测成纤维细胞活力。结果表明，Ag 10wt%和 20wt%组的细菌活性分别降低了 11.8%和 15.4%。当添加 5wt%15wt%的 NaF 时，细菌数量减少到 4.2%65.4%，而当添加 20wt%的 NaF 时，细菌数量增加了 29.4%。无论 Ag 和 NaF 的含量如何，所有氧化锆标本的细胞活力均高于 70%。在本研究的限制内，发现涂覆含 Ag 和 NaF 的玻璃陶瓷粉末的氧化锆可以减少 的黏附，但对成骨细胞的激活没有影响。
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