Spatial and Temperature Resolutions of Magnetic Nanoparticle Temperature Imaging with a Scanning Magnetic Particle Spectrometer.

This paper quantitatively investigates the spatial and temperature resolutions of magnetic nanoparticle (MNP) temperature imaging with a multiline phantom filled with MNPs. The multiline phantom in total consists of seven lines with different distances between two adjacent lines. A scanning magnetic particle spectrometer is used to measure the spatial distributions of the MNP harmonics for MNP concentration and temperature imaging, whereas an iterative deconvolution method is used to improve the spatial resolution. A modulation transfer function calculated from the MNP concentration image is used to quantitatively present the spatial resolution, whereas the standard deviation of the measured temperatures is used to quantitatively present the temperature resolution. The spatial resolution is about 4 mm while the temperature resolution is about 1.0 K without deconvolution. With increasing the number of the iterative loops in the deconvolution, the spatial resolution is improved to 2 mm while the temperature resolution is worsened to about 9.6 K due to deconvolution-based oscillation.