Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia.
FrieslandCampina, 3818 LE Amersfoort, The Netherlands.
Int J Environ Res Public Health. 2018 Oct 23;15(11):2332. doi: 10.3390/ijerph15112332.
The present study aimed to report the prevalence of anaemia and iron deficiency (ID) and to explore the associations among socio-demographic characteristics, nutritional status and inflammation status in the occurrence of anaemia and ID in a nationally representative sample of Malaysian primary schoolchildren. Using data from the South East Asian Nutrition Surveys (SEANUTS), 544 Malaysian children aged 7 to 12 years were included in this secondary analysis. Blood samples were drawn for haemoglobin and serum ferritin analysis while C-reactive protein (CRP) and α-1-acid glycoprotein (AGP) were measured to detect inflammation. Prevalence of anaemia and ID were 4.0% and 5.2%, respectively. There were significantly more anaemic indigenous children (9.9%) than Chinese children (0.6%). Correction for inflammation did not change the prevalence of ID. More overweight/obese children than thin/normal weight children were found to have elevated acute phase protein (APP). Children with elevated inflammatory markers had significantly higher ferritin level than children without inflammation. Periodic health assessments of anaemia and ID at the population level to monitor and clarify the epidemiology of health problems are required to inform public health policies and strategies.
本研究旨在报告马来西亚小学生贫血和缺铁（ID）的流行情况，并探讨社会人口特征、营养状况和炎症状态与贫血和 ID 发生之间的关系。本研究使用了东南亚营养调查（SEANUTS）的数据，共纳入了 544 名 7 至 12 岁的马来西亚儿童。采集血样进行血红蛋白和血清铁蛋白分析，同时测量 C 反应蛋白（CRP）和α-1-酸性糖蛋白（AGP）以检测炎症。贫血和 ID 的患病率分别为 4.0%和 5.2%。土著儿童的贫血患病率（9.9%）明显高于华人儿童（0.6%）。炎症校正并未改变 ID 的患病率。与消瘦/正常体重的儿童相比，超重/肥胖的儿童中急性时相蛋白（APP）升高的比例更高。有炎症标志物升高的儿童的铁蛋白水平明显高于没有炎症的儿童。需要对人群进行贫血和 ID 的定期健康评估，以监测和阐明健康问题的流行病学情况，为公共卫生政策和策略提供信息。
