Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19146, USA.
Department of Psychology, University of Pennsylvania, Philadelphia, PA, 19146, USA.
Nat Commun. 2018 Oct 25;9(1):4437. doi: 10.1038/s41467-018-06876-w.
Focal electrical stimulation of the brain incites a cascade of neural activity that propagates from the stimulated region to both nearby and remote areas, offering the potential to control the activity of brain networks. Understanding how exogenous electrical signals perturb such networks in humans is key to its clinical translation. To investigate this, we applied electrical stimulation to subregions of the medial temporal lobe in 26 neurosurgical patients fitted with indwelling electrodes. Networks of low-frequency (5-13 Hz) spectral coherence predicted stimulation-evoked increases in theta (5-8 Hz) power, particularly when stimulation was applied in or adjacent to white matter. Stimulation tended to decrease power in the high-frequency broadband (HFB; 50-200 Hz) range, and these modulations were correlated with HFB-based networks in a subset of subjects. Our results demonstrate that functional connectivity is predictive of causal changes in the brain, capturing evoked activity across brain regions and frequency bands.
大脑的焦点电刺激引发一连串的神经活动，从受刺激的区域传播到附近和远程区域，从而有可能控制大脑网络的活动。了解外源性电信号如何在人类中干扰这些网络是其临床转化的关键。为了研究这一点，我们对 26 名接受内置电极的神经外科患者的内侧颞叶亚区进行了电刺激。低频（5-13 Hz）谱相干性网络预测刺激诱发的θ波（5-8 Hz）功率增加，特别是当刺激施加在白质内或附近时。刺激往往会降低高频宽带（HFB；50-200 Hz）范围内的功率，并且这些调制与一部分受试者的 HFB 基网络相关。我们的结果表明，功能连接性可预测大脑中因果变化，捕获跨脑区和频带的诱发电活动。
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