Aviation and Nautical Medical Center, Navy General Hospital, Beijing 100048, China.
Nanoscale. 2018 Nov 8;10(43):20234-20245. doi: 10.1039/c8nr07865c.
Rapid bleeding control is increasingly important in current civilian and military emergency medicine, but the rapid hemostasis achieved with current hemostatic products is often unsafe. In this study, mesoporous silica nanoparticles (MSNs) with large pores were coordinated with a glycerol-modified N-alkylated chitosan sponge (GACS) to develop a rapid and safe hemostatic sponge. Due to its coagulation-promoting structure, MSN-GACS exhibited unique hemostatic potency in serial in vitro coagulation tests. In addition to enhanced platelet adhesion and whole blood absorption, MSN-GACS exhibited better biocompatibility than Combat Gauze (CG), which is popular in the US military. Furthermore, in rabbit femoral artery and liver injury in vivo models, MSN-GACS showed better hemostatic efficiency and lower cardiovascular toxicity than CG. In conclusion, MSN-GACS is an excellent prehospital hemostatic agent for first-aid applications.
快速止血在当前的民用和军事紧急医学中变得越来越重要，但目前止血产品所实现的快速止血往往是不安全的。在这项研究中，我们将大孔介孔硅纳米粒子（MSNs）与甘油修饰的 N-烷基化壳聚糖海绵（GACS）配位，开发出一种快速、安全的止血海绵。由于其促凝结构，MSN-GACS 在一系列体外凝血试验中表现出独特的止血效力。除了增强血小板黏附和全血吸收外，MSN-GACS 的生物相容性优于美国军队广泛使用的 Combat Gauze（CG）。此外，在兔股动脉和肝脏损伤的体内模型中，MSN-GACS 表现出比 CG 更好的止血效率和更低的心血管毒性。总之，MSN-GACS 是一种优秀的急救用院前止血剂。
