Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, China.
Pflugers Arch. 2024 Nov;476(11):1625-1643. doi: 10.1007/s00424-024-02989-y. Epub 2024 Jul 17.
Neuropathic pain (NPP) is a refractory pain syndrome, caused by damage or disease of the somatosensory nervous system and characterized by spontaneous pain, hyperalgesia, abnormal pain and sensory abnormality. Non-coding RNAs (ncRNAs), including microRNA (miRNA), long non-coding RNA (lncRNA), circular RNA (circRNA) and Piwi interacting RNA (piRNA), play a notable role in initiation and maintenance of NPP. In this review, we summarize the role of ncRNAs in NPP and their underlaying mechanism. Generally, ncRNAs are interacted with mRNA, protein or DNA to regulate the molecules and signals assciated with neuroinflammation, ion channels, neurotrophic factors and others, and then involved in the occurrence and development of NPP. Therefore, this review not only contributes to deepen our understanding of the pathophysiological mechanism of NPP, but also provides theoretical basis for the development of new therapy strategies for this disorder.
神经病理性疼痛（NPP）是一种难治性疼痛综合征，由躯体感觉神经系统的损伤或疾病引起，其特征为自发性疼痛、痛觉过敏、异常疼痛和感觉异常。非编码 RNA（ncRNA），包括 microRNA（miRNA）、长非编码 RNA（lncRNA）、环状 RNA（circRNA）和 Piwi 相互作用 RNA（piRNA），在 NPP 的发生和维持中起着显著的作用。在这篇综述中，我们总结了 ncRNA 在 NPP 中的作用及其潜在机制。一般来说，ncRNA 与 mRNA、蛋白质或 DNA 相互作用，调节与神经炎症、离子通道、神经营养因子等相关的分子和信号，从而参与 NPP 的发生和发展。因此，本综述不仅有助于加深我们对 NPP 病理生理机制的理解，也为这一疾病的新治疗策略的发展提供了理论基础。
