Zhao Xi, Zhang Hui-Wen, Xu Rui-Xia, Guo Yuan-Lin, Zhu Cheng-Gang, Wu Na-Qiong, Gao Ying, Li Jian-Jun
State Key Laboratory of Cardiovascular Disease, Division of Dyslipidemia, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing 100037, China.
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Per Med. 2018 Nov;15(6):521-529. doi: 10.2217/pme-2018-0046. Epub 2018 Oct 26.
The link of oxidized-low-density lipoprotein (ox-LDL) with premature coronary artery disease (CAD) has previously been less examined. Materials & methods: A total of 1217 patients with angiography-proven CAD were consecutively enrolled and divided into very-early CAD (VECAD), early CAD and late CAD subgroups. And 72 normal control of VECAD were examined. All the subjects were followed-up for an average of 31 months.
Patients with VECAD had higher ox-LDL levels; and logistic regression analysis indicated that ox-LDL was an independent risk factor for VECAD among patients with CAD (adjusted odds ratio: 1.024; p < 0.001). The Kaplan-Meier analysis revealed that VECAD patients had lower event-free survival (p < 0.01, respectively).
Elevated plasma ox-LDL level is independently associated with the presence and cardiovascular events in VECAD patients, suggesting that ox-LDL may be a prognostic predictor for VECAD.
氧化型低密度脂蛋白（ox-LDL）与早发性冠状动脉疾病（CAD）之间的联系此前较少受到研究。材料与方法：连续纳入1217例经血管造影证实患有CAD的患者，并将其分为极早期CAD（VECAD）、早期CAD和晚期CAD亚组。同时检查了72例VECAD的正常对照者。所有受试者平均随访31个月。
VECAD患者的ox-LDL水平较高；逻辑回归分析表明，ox-LDL是CAD患者中VECAD的独立危险因素（调整后的优势比：1.024；p<0.001）。Kaplan-Meier分析显示，VECAD患者的无事件生存率较低（p<0.01）。
血浆ox-LDL水平升高与VECAD患者的患病情况及心血管事件独立相关，提示ox-LDL可能是VECAD的预后预测指标。
