应用运动障碍学会帕金森病相关痴呆工作组标准对帕金森病认知评定量表的验证
Validation of the Parkinson's Disease-Cognitive Rating Scale Applying the Movement Disorder Society Task Force Criteria for Dementia Associated with Parkinson's Disease.
作者信息
Serrano-Dueñas Marcos, Serrano Maite, Villena Diana, Granda David
机构信息
Abnormal Movement Unit Neurology Service Carlos Andrade Marin Hospital Quito Ecuador.
Faculty of Medicine Pontifical Catholic University of Ecuador Quito Ecuador.
出版信息
Mov Disord Clin Pract. 2016 Mar 1;4(1):51-57. doi: 10.1002/mdc3.12338. eCollection 2017 Jan-Feb.
BACKGROUND
The authors studied the measurement properties of the Parkinson's Disease-Cognitive Rating Scale (PD-CRS) compared with Movement Disorders Society Task Force (MDS-TF) criteria for the diagnosis of dementia in patients with Parkinson's disease.
METHODS
The sample consisted of 223 patients who were diagnosed in accordance with the United Kingdom Parkinson's Disease Society Brain Bank who were assessed with both the MDS-TF and the PD-CRS criteria (in addition to other instruments) without the assessors' knowledge of previous results. Internal consistency was studied (homogeneity of the items and Guttmann's λ values were obtained) in addition to convergent, divergent, and discriminative validity. The receiver operating characteristic curve was obtained, and the cutoff point at which the PD-CRS had the greatest efficiency was analyzed.
RESULTS
The internal consistency was shown to be adequate, with a λ value of 0.821. A floor effect was observed in 4 of the items (Sustained Attention, Working Memory, Immediate Verbal Memory, and Alternating Verbal Fluency), and 1 item showed a ceiling effect (Clock Copying). The scale adequately discriminated patients with and without dementia (Kruskal-Wallis; ≤0.000). The area under the curve was 0.899. With a cutoff score of 62 (from a possible score of 134), the scale achieved 94% sensitivity and 99% specificity.
CONCLUSIONS
The PD-CRS has adequate measurement properties and is a valid tool for studying the presence of dementia in patients with Parkinson's disease.
背景
作者研究了帕金森病认知评定量表（PD-CRS）与运动障碍协会特别工作组（MDS-TF）诊断帕金森病患者痴呆标准相比的测量特性。
方法
样本包括223例根据英国帕金森病协会脑库标准诊断的患者，他们接受了MDS-TF和PD-CRS标准的评估（以及其他工具），评估者事先不知道先前的结果。除了收敛效度、发散效度和区分效度外，还研究了内部一致性（获得项目同质性和古特曼λ值）。获得了受试者工作特征曲线，并分析了PD-CRS效率最高时的截断点。
结果
内部一致性显示良好，λ值为0.821。在4个项目（持续注意力、工作记忆、即时言语记忆和交替言语流畅性）中观察到地板效应，1个项目（时钟复制）显示天花板效应。该量表能充分区分痴呆患者和非痴呆患者（Kruskal-Wallis检验；P≤0.000）。曲线下面积为0.899。截断分数为62（满分134）时该量表的灵敏度为94%，特异度为99%。
结论
PD-CRS具有良好的测量特性，是研究帕金森病患者痴呆症存在情况的有效工具。
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