Bigliardi Enrico, Cantoni Anna Maria, De Cesaris Valeria, Denti Laura, Conti Virna, Bertocchi Mara, Di Ianni Francesco, Parmigiani Enrico, Grolli Stefano
Department of Veterinary Medical Science, University of Parma, Via del Taglio 10, 43100 Parma, Italy.
Can J Vet Res. 2018 Oct;82(4):264-270.
Abnormalities of the canine prostate gland, in particular, benign hyperplasia and cysts, are frequent in dogs over 5 years of age. Treatment strategies for dogs with prostatic cysts include ultrasound-guided percutaneous drainage with alcohol sclerotherapy, reduction surgery, and omentalization. The aim of this study was to evaluate the use of platelet-rich plasma (PRP) for the treatment of prostatic cysts in dogs. Ten mixed breed adult male dogs were included in the study. Percutaneous drainage was performed prior to ultrasound-guided PRP injection with a 21G spinal needle. The PRP dose contained half of the solution drained from the cyst. Follow-ups were performed 6, 12, 24, and 60 d after treatment. Ten prostatic cysts were successfully treated with PRP after the ultrasound-guided drainage of the cystic cavities. No side effects were observed during the procedures. After the introduction of PRP, cysts detected by ultrasound appeared hypoechoic. On the sixth day, the hypoechoic appearance was maintained and margins were still identifiable. At 24-day and 60-day follow-ups, cysts were no longer detectable by ultrasound. One of the ten dogs had to be euthanized because of the presence of a malignant mesenchymal neoplasm of the oral cavity (fibroblastic sarcoma) and histological examination of serial sections of the prostate gland was performed. Histologic evaluation 1 year after treatment showed a regression of the cystic lesion injected with PRP. The therapy, which uses PRP injection in combination with ultrasound-guided drainage, can be considered a safe and effective strategy for the treatment of prostatic cysts in dogs.
犬前列腺异常，尤其是良性增生和囊肿，在5岁以上的犬中很常见。前列腺囊肿犬的治疗策略包括超声引导下经皮穿刺引流联合乙醇硬化疗法、减压手术和网膜包裹术。本研究的目的是评估富血小板血浆（PRP）在犬前列腺囊肿治疗中的应用。该研究纳入了10只成年杂种雄性犬。在超声引导下用21G脊椎穿刺针注射PRP之前进行经皮穿刺引流。PRP剂量为从囊肿中抽出液体量的一半。在治疗后6、12、24和60天进行随访。在对囊腔进行超声引导下引流后，10个前列腺囊肿成功接受了PRP治疗。在操作过程中未观察到副作用。引入PRP后，超声检查发现囊肿呈低回声。在第6天，低回声表现持续存在，边界仍可辨认。在24天和60天的随访中，超声检查不再能检测到囊肿。10只犬中有1只因口腔恶性间叶肿瘤（纤维母细胞肉瘤）而实施安乐死，并对前列腺连续切片进行了组织学检查。治疗1年后的组织学评估显示，注射PRP的囊肿性病变有所消退。将PRP注射与超声引导下引流相结合的治疗方法可被认为是治疗犬前列腺囊肿的一种安全有效的策略。
