Ainslie-Garcia Margaret H, Farzan Abdolvahab, Newman Jane E, Friendship Robert M, Lillie Brandon N
Department of Pathobiology (Ainslie-Garcia, Farzan, Newman, Lillie) and Department of Population Medicine (Farzan, Newman, Friendship), University of Guelph, Guelph, Ontario N1G 2W1.
Can J Vet Res. 2018 Oct;82(4):249-255.
is an important cause of foodborne illnesses in humans. Food-producing animals, including swine, are a major source of in food products. This study investigated on farm fecal shedding in pigs at different production stages - from weaning to marketing - and its association with the presence of in tissues at slaughter. Fourteen groups from 8 commercial farrowing sources (N = 809 pigs) were monitored 5 times from birth to slaughter. Fecal and tissue samples were collected from pigs and cultured for A survey was conducted to collect farm management information. A multi-level mixed-effects logistic regression modelling method was used to analyze shedding over time and the association between shedding and the presence of in tissue samples. was recovered from 13% (421/3339) of fecal samples collected from 809 pigs over the course of the study. Overall, 35% (284) of pigs shed at least once, while 12% (99) shed more than once. shedding increased as pigs aged ( = 0.01) and increased in the summer months ( < 0.01). was isolated from tissue samples collected from 23% (134/580) of pigs; however, the presence of at slaughter was not associated with on farm shedding. The seasonal trend in shedding and its association with age may be used to identify high-risk groups and implement more effective control measures accordingly. The identification of repeat shedders warrants interventions that target this source of infection on swine farms.
是人类食源性疾病的一个重要病因。包括猪在内的产肉动物是食品中该病菌的主要来源。本研究调查了猪在不同生产阶段(从断奶到上市)的农场粪便排菌情况及其与屠宰时组织中该病菌存在情况的关联。对来自8个商业分娩源头的14组猪(N = 809头猪)从出生到屠宰进行了5次监测。从猪身上采集粪便和组织样本并进行该病菌培养。开展了一项调查以收集农场管理信息。采用多层次混合效应逻辑回归建模方法分析随时间变化的病菌排菌情况以及粪便排菌与组织样本中病菌存在情况之间的关联。在本研究过程中,从809头猪采集的粪便样本中有13%(421/3339)检测出该病菌。总体而言,35%(284头)的猪至少有一次粪便排菌,而12%(99头)的猪有不止一次排菌。随着猪龄增长,病菌排菌情况增加(P = 0.01),且在夏季月份排菌情况增加(P < 0.01)。从23%(134/580)的猪的组织样本中分离出该病菌;然而,屠宰时该病菌的存在与农场排菌情况无关。病菌排菌的季节性趋势及其与年龄的关联可用于识别高危群体并据此实施更有效的控制措施。识别出反复排菌者需要采取针对猪场这一感染源的干预措施。