Bäumer Tobias, Sajin Valeria, Münchau Alexander
Department of Paediatric and Adult Movement Disorders and Neuropsychiatry Institute of Neurogenetics University of Lübeck Lübeck Germany.
Department of Neurology University Medical Center Hamburg-Eppendorf Hamburg Germany.
Mov Disord Clin Pract. 2016 Jul 23;4(3):437-440. doi: 10.1002/mdc3.12399. eCollection 2017 May-Jun.
The aim of this work is to report the distribution of clinical phenomenology, demographic variables, and delay of diagnosis in a cohort of patients with childhood-onset movement disorders. Personally examined patients with childhood-onset movement disorders apart from those with cerebral palsy are reported. A total of 606 patients were included. The majority had tic disorders (346; 57%) followed by dystonia (72; 12%); other movement disorders were less frequent (<5%). Mean onset age of patients with tics was 7.4 years ± 3.8 standard deviation; mean delay of diagnosis was 9.9 ± 11 years. Mean onset age of other movement disorders was 8.6 ± 5.7 years; mean delay of diagnosis was 11.1 ± 12.5 years. Psychogenic movement disorders had a later onset than all other movement disorders ( < 0.01) apart from tremor and "other movement disorders." Dystonias had a longer delay of diagnosis than psychogenic movement disorders ( < 0.038). The diagnostic delay of childhood-onset movement disorders is considerable, indicating that they are probably under-recognized.
这项工作的目的是报告一组儿童期起病的运动障碍患者的临床现象学分布、人口统计学变量及诊断延迟情况。本文报告了除脑瘫患者外亲自检查的儿童期起病的运动障碍患者。共纳入606例患者。大多数患者患有抽动障碍（346例，占57%），其次是肌张力障碍（72例，占12%）；其他运动障碍较少见（<5%）。抽动障碍患者的平均起病年龄为7.4岁±3.8标准差；平均诊断延迟为9.9±11年。其他运动障碍的平均起病年龄为8.6±5.7岁；平均诊断延迟为11.1±12.5年。心理性运动障碍的起病时间晚于除震颤和“其他运动障碍”外的所有其他运动障碍（<0.01）。肌张力障碍的诊断延迟时间比心理性运动障碍长（<0.038）。儿童期起病的运动障碍的诊断延迟相当可观，表明它们可能未得到充分认识。
