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复杂型运动障碍:诊断与治疗的最新进展。

Complex dystonias: an update on diagnosis and care.

机构信息

Institute of Systems Motor Science, University of Lübeck, Center for Brain, Behavior and Metabolism, Ratzeburger Allee 160, 23538, Lübeck, Germany.

出版信息

J Neural Transm (Vienna). 2021 Apr;128(4):431-445. doi: 10.1007/s00702-020-02275-y. Epub 2020 Nov 13.

Abstract

Complex dystonias are defined as dystonias that are accompanied by neurologic or systemic manifestations beyond movement disorders. Many syndromes or diseases can present with complex dystonia, either as the cardinal sign or as part of a multi-systemic manifestation. Complex dystonia often gradually develops in the disease course, but can also be present from the outset. If available, the diagnostic workup, disease-specific treatment, and management of patients with complex dystonias require a multi-disciplinary approach. This article summarizes current knowledge on complex dystonias with a particular view of recent developments with respect to advances in diagnosis and management, including causative treatments.

摘要

复杂性局灶性肌张力障碍是指除运动障碍外,还伴有神经或系统性表现的局灶性肌张力障碍。许多综合征或疾病可表现为复杂性局灶性肌张力障碍,或是主要表现,或是多系统表现的一部分。复杂性局灶性肌张力障碍通常在疾病过程中逐渐发展,但也可从一开始就存在。如果有条件,复杂性局灶性肌张力障碍患者的诊断评估、针对特定疾病的治疗和管理需要采取多学科方法。本文特别关注诊断和管理方面的最新进展,包括病因治疗,总结了目前复杂性局灶性肌张力障碍的相关知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11e3/8099829/18140c1b3195/702_2020_2275_Fig1_HTML.jpg

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