Lalvay Lissette, Lara Miguel, Mora Andrea, Alarcón Fernando, Fraga Manuel, Pancorbo Jesús, Marina José Luis, Mena María Ángeles, Lopez Sendón Jose Luis, García de Yébenes Justo
Servicio de Neurología Hospital Eugenio Espejo Quito Ecuador.
Taniwa Solutions Madrid Spain.
Mov Disord Clin Pract. 2016 Aug 3;4(3):316-322. doi: 10.1002/mdc3.12410. eCollection 2017 May-Jun.
There is great interest in developing simple, user-friendly, and inexpensive tools for the quantification and elucidation of motor deficits in patients with Parkinson's disease (PD). These systems could help to monitor the clinical status of patients with PD, to develop better treatments, and to identify individuals who have subtle motor signs that might pass unnoticed in the conventional neurological examination.
Mememtum, a smartphone application that allows for the quantification of several parameters of movement, such as regularity, rhythm, and changes in the number of taps while taping with a single finger and with alternating fingers, was developed and then tested in a pilot study in Madrid and in an extensive study in Quito, Ecuador.
Almost all patients could successfully perform single-finger tapping, but approximately 10% of patients with severe parkinsonism had problems taping with alternating fingers. The results revealed changes in the regularity of the pressure applied while tapping and a reduction in the number of taps on the device screen when alternating tapping among patients who had idiopathic PD and vascular parkinsonism compared with controls and individuals who had prediagnostic motor abnormalities of PD.
Applications available in smartphones could be used for investigation and treatment of patients with PD, but much research is needed to optimize the ideal parameters to be investigated and the potential usefulness of this technique for patients with PD in different stages of the disease.
开发用于量化和阐明帕金森病（PD）患者运动功能障碍的简单、用户友好且廉价的工具具有重大意义。这些系统有助于监测PD患者的临床状态，开发更好的治疗方法，并识别那些在传统神经学检查中可能被忽视的有细微运动体征的个体。
开发了一款名为Mememtum的智能手机应用程序，它可以量化多种运动参数，如规律性、节奏以及单指点击和交替手指点击时点击次数的变化，然后在马德里进行了一项试点研究，并在厄瓜多尔基多进行了一项广泛研究中对其进行测试。
几乎所有患者都能成功进行单指点击，但约10%的重度帕金森病患者在交替手指点击时存在困难。结果显示，与对照组以及有PD诊断前运动异常的个体相比，特发性PD和血管性帕金森病患者在交替点击时，点击时施加压力的规律性发生了变化，且设备屏幕上的点击次数减少。
智能手机中可用的应用程序可用于PD患者的调查和治疗，但需要进行大量研究以优化待研究的理想参数以及该技术对处于疾病不同阶段的PD患者的潜在效用。
