（S）-9-（3-羟基-2-膦酰甲氧基丙基）腺嘌呤对新分离的临床水痘带状疱疹病毒株的体外活性
In vitro activity of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against newly isolated clinical varicella-zoster virus strains.
作者信息
Baba M, Konno K, Shigeta S, De Clercq E
出版信息
Eur J Clin Microbiol. 1987 Apr;6(2):158-60. doi: 10.1007/BF02018198.
PMID:3036498
Abstract
The highly potent and selective anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA] was found to inhibit in vitro the replication of a number of clinical varicella-zoster virus strains within the concentration range of 0.63-5.7 ng/ml. With a mean 50% inhibitory concentration of 1.8 ng/ml and selectivity index of 29000, (S)-HPMPA is one of the most potent and most selective varicella-zoster virus inhibitors discovered to date.
摘要
强效选择性抗DNA病毒剂（S）-9-（3-羟基-2-膦酰甲氧基丙基）腺嘌呤[（S）-HPMPA]在体外能抑制多种临床水痘带状疱疹病毒株的复制，其浓度范围为0.63-5.7纳克/毫升。（S）-HPMPA的平均50%抑制浓度为1.8纳克/毫升，选择性指数为29000，是迄今为止发现的最有效、最具选择性的水痘带状疱疹病毒抑制剂之一。
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