所选抗病毒化合物对新分离临床水痘带状疱疹病毒株的抑制作用。

Inhibitory effects of selected antiviral compounds on newly isolated clinical varicella-zoster virus strains.

作者信息

Baba M, Konno K, Shigeta S, De Clercq E

出版信息

Tohoku J Exp Med. 1986 Mar;148(3):275-83. doi: 10.1620/tjem.148.275.

DOI:10.1620/tjem.148.275

Abstract

Nine anti-herpes compounds, idoxuridine (IDU), bromovinyldeoxyuridine (BVDU), bromovinylarabinofuranosylurasil (BVaraU), carbocyclic bromovinyldeoxyuridine (C-BVDU), chloroethyldeoxyuridine (CEDU), acyclovir (ACV), dihydroxypropoxymethylguanine (DHPG), adenine arabinoside (Ara-A), and phosphonoformate (PFA) were examined for their inhibitory activities against the replication of twenty-six newly isolated clinical strains of varicella-zoster virus (VZV) in human embryonic fibroblast cell cultures. The order of (decreasing) efficacy was: BVaraU greater than BVDU greater than or equal to C-BVDU greater than CEDU greater than or equal to IDU greater than ACV greater than Ara-A greater than DHPG greater than PFA. There was little variation in the susceptibility of the 26 VZV strains to each particular compound, except for one strain which was resistant to IDU.

摘要

研究了九种抗疱疹化合物，即碘苷（IDU）、溴乙烯脱氧尿苷（BVDU）、溴乙烯阿拉伯呋喃糖基尿嘧啶（BVaraU）、碳环溴乙烯脱氧尿苷（C-BVDU）、氯乙基脱氧尿苷（CEDU）、阿昔洛韦（ACV）、二羟基丙氧基甲基鸟嘌呤（DHPG）、阿糖腺苷（Ara-A）和膦甲酸（PFA）对26株新分离的水痘-带状疱疹病毒（VZV）临床毒株在人胚成纤维细胞培养物中复制的抑制活性。（从高到低的）效力顺序为：BVaraU＞BVDU≥C-BVDU＞CEDU≥IDU＞ACV＞Ara-A＞DHPG＞PFA。除了一株对IDU耐药的毒株外，26株VZV毒株对每种特定化合物的敏感性几乎没有差异。