（S）-9-（3-羟基-2-膦酰甲氧基丙基）腺嘌呤和2'-去甲环鸟苷酸对腺病毒体外复制的选择性抑制作用。
Selective inhibitory effect of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 2'-nor-cyclic GMP on adenovirus replication in vitro.
作者信息
Baba M, Mori S, Shigeta S, De Clercq E
出版信息
Antimicrob Agents Chemother. 1987 Feb;31(2):337-9. doi: 10.1128/AAC.31.2.337.
Abstract
The inhibitory effects of 20 selected antiviral compounds on the replication of adenoviruses (types 1 to 8) in vitro were investigated. While 18 compounds were ineffective, 2 compounds, namely (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA] and 9-[(2-hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxymethyl]guanine P-oxide (2'-nor-cyclic GMP), were highly effective against all adenovirus types assayed in human embryonic fibroblast cultures. Their 50% inhibitory doses were 1.1 microgram/ml for (S)-HPMPA and 4.1 micrograms/ml for 2'-nor-cyclic GMP. They were nontoxic for the host cells at the effective antiviral doses.
摘要
研究了20种选定的抗病毒化合物对腺病毒（1至8型）在体外复制的抑制作用。18种化合物无效，而2种化合物，即（S）-9-（3-羟基-2-膦酰甲氧基丙基）腺嘌呤[（S）-HPMPA]和9- [（2-羟基-1,3,2-二氧磷杂环己烷-5-基）氧甲基]鸟嘌呤P-氧化物（2'-去甲环鸟苷），对人胚成纤维细胞培养物中测定的所有腺病毒类型均具有高效。它们的50%抑制剂量对于（S）-HPMPA为1.1微克/毫升，对于2'-去甲环鸟苷为4.1微克/毫升。在有效的抗病毒剂量下，它们对宿主细胞无毒。
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本文引用的文献
1
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Science. 1978 May 5;200(4341):563-5. doi: 10.1126/science.200.4341.563.
2
Antiviral, antimetabolic and antineoplastic activities of 2'- or 3'-amino or -azido-substituted deoxyribonucleosides.2'-或3'-氨基或叠氮基取代的脱氧核糖核苷的抗病毒、抗代谢及抗肿瘤活性
Biochem Pharmacol. 1980 Jun 15;29(12):1849-51. doi: 10.1016/0006-2952(80)90149-5.
3
Antiviral activity of C-5 substituted tubercidin analogues.C-5取代杀结核菌素类似物的抗病毒活性。
J Med Chem. 1984 Mar;27(3):285-92. doi: 10.1021/jm00369a010.
4
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Antiviral Res. 1983 Mar;3(1):17-24. doi: 10.1016/0166-3542(83)90011-6.
5
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J Infect Dis. 1983 Mar;147(3):576-84. doi: 10.1093/infdis/147.3.576.
6
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Cell. 1982 Dec;31(3 Pt 2):613-23. doi: 10.1016/0092-8674(82)90317-8.
7
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Am J Med. 1980 May;68(5):725-32. doi: 10.1016/0002-9343(80)90262-4.
8
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9
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10
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